Mactier Helen, McLaughlin Poppy, Gillis Cheryl, Osselton Michael David
Neonatal Unit, Princess Royal Maternity, Glasgow, United Kingdom.
Department of Anthropology and Forensic Science, Bournemouth University, Fern Barrow, Poole, United Kingdom.
Am J Perinatol. 2017 Jul;34(9):918-921. doi: 10.1055/s-0037-1600917. Epub 2017 Mar 20.
Neonatal abstinence syndrome (NAS) in infants of methadone-maintained opioid-dependent (MMOD) mothers cannot be predicted in individual cases. We investigated whether variation in infant genotype is associated with severity of NAS. This is a pilot observational cohort study of 21 MMOD mothers and their newborns. Infant buccal swabs were obtained soon after delivery, together with a maternal blood sample for the determination of maternal plasma methadone concentration. Genomic variation in five opioid-related genes (, and ) was ascertained from infant buccal swabs and related to need for pharmacological treatment of NAS. Out of 21 infants, 11 (52%) required treatment for NAS. Mothers of treated infants tended to have been prescribed higher doses of methadone, but plasma methadone concentrations did not differ between mothers of treated or untreated babies. Treated and untreated babies did not differ in terms of method of feeding. Treated infants were more likely to carry the normal (homozygous) allele at 516 and 785 regions of gene ( = 0.015 and 0.023, respectively). There were no differences in any other genes between infants who did or did not require treatment for NAS. Genomic variation in may explain, at least in part, severity of NAS.
对于接受美沙酮维持治疗的阿片类药物依赖（MMOD）母亲所生婴儿的新生儿戒断综合征（NAS），无法在个体病例中进行预测。我们调查了婴儿基因型的变异是否与NAS的严重程度相关。 这是一项对21名MMOD母亲及其新生儿进行的试点观察性队列研究。婴儿出生后不久即采集颊拭子，并采集母亲血样以测定母亲血浆美沙酮浓度。从婴儿颊拭子中确定五个阿片类药物相关基因（、和）的基因组变异，并将其与NAS的药物治疗需求相关联。 在21名婴儿中，11名（52%）需要接受NAS治疗。接受治疗婴儿的母亲往往被开了更高剂量的美沙酮，但治疗婴儿和未治疗婴儿的母亲之间血浆美沙酮浓度并无差异。治疗婴儿和未治疗婴儿在喂养方式上没有差异。接受治疗的婴儿在基因的516和785区域更有可能携带正常（纯合）等位基因（分别为 = 0.015和0.023）。在是否需要接受NAS治疗的婴儿之间，其他任何基因均无差异。 基因的基因组变异可能至少部分解释了NAS的严重程度。
