Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
IEEE Trans Biomed Eng. 2013 Mar;60(3):707-14. doi: 10.1109/TBME.2013.2238672. Epub 2013 Jan 9.
Tissue ablation is an essential procedure for the treatment of many diseases. In the last decade, a nonthermal tissue ablation using intensive pulsed electric fields, called nonthermal irreversible electroporation (NTIRE), has rapidly emerged. The exact mechanisms responsible for cell death by NTIRE, however, are currently unknown. Nevertheless, the technique's remarkable ability to ablate tissue in the proximity of larger blood vessels, to preserve tissue architecture, short procedure duration, and shortened postoperative recovery period rapidly moved NTIRE from bench to bed side. This work provides an overview on the development of NTIRE, its current state-of-the-art, challenges, and future needs.
组织消融是治疗许多疾病的重要手段。在过去的十年中，一种使用高强度脉冲电场的非热组织消融技术，称为非热不可逆电穿孔（NTIRE），迅速发展起来。然而，导致 NTIRE 细胞死亡的确切机制目前尚不清楚。尽管如此，该技术在靠近较大血管的部位消融组织、保持组织结构、缩短手术时间和术后恢复时间方面的显著能力，使得 NTIRE 迅速从实验室走向临床。本文概述了 NTIRE 的发展、现状、挑战和未来需求。
