Choi Min, Lee Hye Sun, Cho Sung Bin
R&D Center, Shenb Co., Ltd, Seoul, Korea.
Department of Biostatistics, Yonsei University College of Medicine, Seoul, Korea.
Clin Cosmet Investig Dermatol. 2023 Jan 13;16:87-97. doi: 10.2147/CCID.S395072. eCollection 2023.
Radiofrequency (RF) oscillations generate thermal tissue reactions, the patterns of which vary depending on the mode and efficiency of energy delivery. The aim of our study was to analyze patterns of RF-induced thermal tissue reactions according to the modes of RF delivery, including continuous and gated modes, using an alternating current, invasive bipolar RF device.
RF energies at frequencies of 1 and 2 MHz were delivered at respective experimental settings into ex vivo bovine liver tissue at a 0.5-mm microneedle penetration depth. The tissue samples were then evaluated thermometrically. A histologic study was performed to evaluate RF-induced thermal tissue reactions at a 3.0-mm microneedle penetration depth.
Thermal imaging study revealed homogenous, well-demarcated, square-shaped zones of RF-induced thermal reactivity on the treated area. Multivariate linear regression analysis revealed that higher temperature elevations immediately after RF treatment (∆T) were positively associated with RF frequency, power, conduction time/pulse pack, and off-time between pulse packs and negatively associated with total off time. In the 1-MHz experimental setting, higher ∆T showed a positive association with power, conduction time/pulse pack, and off-time between pulse packs and a negative association with the number of pulse packs. In the 2-MHz setting, however, higher ∆T was positively associated with only total treatment time.
Thermometric effects during bipolar and gated RF treatments are significantly associated with the frequency, power, and pulse widths and cycles of pulse packs.
射频（RF）振荡会引发组织热反应，其模式会因能量传递的方式和效率而有所不同。我们研究的目的是使用交流电侵入式双极射频设备，根据射频传递模式（包括连续模式和门控模式）分析射频诱导的组织热反应模式。
在各自的实验设置下，将1MHz和2MHz频率的射频能量以0.5mm的微针穿透深度传递到离体牛肝组织中。然后对组织样本进行温度测量评估。进行组织学研究以评估在3.0mm微针穿透深度下射频诱导的组织热反应。
热成像研究显示，在治疗区域出现均匀、界限清晰的方形射频诱导热反应区。多变量线性回归分析显示，射频治疗后即刻的较高温度升高（∆T）与射频频率、功率、传导时间/脉冲组以及脉冲组之间的关闭时间呈正相关，与总关闭时间呈负相关。在1MHz的实验设置中，较高的∆T与功率、传导时间/脉冲组以及脉冲组之间的关闭时间呈正相关，与脉冲组数量呈负相关。然而，在2MHz的设置中，较高的∆T仅与总治疗时间呈正相关。
双极和门控射频治疗期间的温度测量效应与脉冲组的频率、功率、脉冲宽度和周期显著相关。
