Centre de Haute Energie, Centre de Radiothérapie Privé and ADeRTU, Nice, France.
J Neurooncol. 2013 Apr;112(2):223-31. doi: 10.1007/s11060-013-1050-5. Epub 2013 Jan 12.
Papillary tumor of the pineal region (PTPR), recently described as a distinct clinicopathological entity, can show aggressive biological behavior. The optimal therapeutic approach of PTPR has not been well defined. The role of surgery, radiotherapy, and chemotherapy in the treatment of PTPR was analyzed in a large multicenter series. In order to determine factors that influence prognosis, outcome data of a series of 44 patients with histopathologically proven PTPR were retrospectively analyzed. Of the 44 patients, 32 were still alive after a median follow-up of 63.1 months. Twelve patients experienced progressive disease, with seven undergoing two relapses and five more than two. Median overall survival (OS) was not achieved. Median progression-free survival (PFS) was 58.1 months. Only gross total resection and younger age were associated with a longer OS, radiotherapy and chemotherapy having no significant impact. PFS was not influenced by gross total resection. Radiotherapy and chemotherapy had no significant effect. This retrospective series confirms the high risk of recurrence in PTPR and emphasizes the importance of gross total resection. However, our data provide no evidence for a role of adjuvant radiotherapy or chemotherapy in the treatment of PTPR.
松果体区乳头状肿瘤（PTPR），最近被描述为一种独特的临床病理实体，可能表现出侵袭性的生物学行为。PTPR 的最佳治疗方法尚未明确。在一项大型多中心系列研究中分析了手术、放疗和化疗在 PTPR 治疗中的作用。为了确定影响预后的因素，回顾性分析了 44 例经组织病理学证实的 PTPR 患者的系列结果数据。在这 44 例患者中，32 例在中位随访 63.1 个月后仍存活。12 例患者出现进行性疾病，其中 7 例发生两次复发，5 例以上发生两次复发。中位总生存期（OS）未达到。中位无进展生存期（PFS）为 58.1 个月。仅大体全切除和年龄较小与较长的 OS 相关，放疗和化疗无显著影响。PFS 不受大体全切除的影响。放疗和化疗没有显著影响。本回顾性系列研究证实了 PTPR 复发风险高，并强调了大体全切除的重要性。然而，我们的数据没有提供辅助放疗或化疗在 PTPR 治疗中的作用的证据。
