替莫唑胺化疗辅助治疗松果体区乳头状肿瘤。
Adjuvant temozolomide chemotherapy for treatment of papillary tumor of the pineal region.
机构信息
Neurosurgery, Department of Neurological Sciences, Ospedale Maggiore, Mangiagalli e Regina Elena, Fondazione Policlinico, Istituto di Ricovero e Cura a Carattere Scientifico, and Department of Medicine, Surgery, and Dentistry, University of Milan, Milan, Italy.
出版信息
World Neurosurg. 2011 Jul-Aug;76(1-2):160-3. doi: 10.1016/j.wneu.2010.10.039.
BACKGROUND
We present a personal case of papillary pineocytoma in a 42-year-old woman.
METHODS
The lesion was first treated surgically both for diagnostic aims and for resolution of the mass effect causing hydrocephalus and correlated neurological disturbances. Because the tumor recurred after surgery and radiotherapy, we decided to further treat the patient with chemotherapy, in particular with temozolomide.
RESULTS
Currently, almost 9 years after the first treatment, the patient is symptom-free and follow-up magnetic resonance imaging shows no tumor recurrence.
CONCLUSION
Although surgery should be considered the first-choice therapy, we think that temozolomide can be a valid option in case of recurrence of these rare tumors.
背景
我们报告了一例 42 岁女性的毛细胞型松果体细胞瘤。
方法
该病变最初通过手术进行治疗，目的是明确诊断，缓解因肿块效应引起的脑积水和相关的神经功能障碍。由于肿瘤在手术后和放疗后复发，我们决定进一步对患者进行化疗，特别是使用替莫唑胺。
结果
目前，在首次治疗后近 9 年，患者无症状，随访磁共振成像显示无肿瘤复发。
结论
尽管手术应被视为首选治疗方法，但我们认为替莫唑胺在这些罕见肿瘤复发时是一种有效的选择。
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