一种不饱和脂肪族醇作为一种天然配体与小鼠气味受体结合。
An unsaturated aliphatic alcohol as a natural ligand for a mouse odorant receptor.
机构信息
Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan.
出版信息
Nat Chem Biol. 2013 Mar;9(3):160-2. doi: 10.1038/nchembio.1164. Epub 2013 Jan 13.
We report the identification of a physiological receptor-volatile pair in the mouse olfactory system. By activity-guided fractionation of exocrine gland extracts and subsequent chemical analysis, (Z)-5-tetradecen-1-ol was identified as a natural ligand for a mouse odorant receptor. (Z)-5-tetradecen-1-ol is excreted into male mouse urine under androgen control and enhances urine attractiveness to female mice. This report is to our knowledge the first to describe natural product-based deorphanization of an odorant receptor.
我们报告了在小鼠嗅觉系统中鉴定出一对生理受体-挥发性配体。通过对外分泌腺提取物的活性导向分离和随后的化学分析，鉴定出(Z)-5-十四碳烯-1-醇是一种天然的小鼠气味受体配体。(Z)-5-十四碳烯-1-醇在雄激素的控制下被排泄到雄性小鼠的尿液中，并增强了尿液对雌性小鼠的吸引力。据我们所知，这是首次描述基于天然产物的气味受体的非孤儿化。
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