Division of Pediatric Allergy Asthma and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkuo, and College of Medicine, Chang Gung University, 5, Fu-Hsin Street, Taoyuan, Taiwan.
Rheumatol Int. 2013 Jul;33(7):1805-11. doi: 10.1007/s00296-012-2643-6. Epub 2013 Jan 12.
This population-based study aimed to determine the trend of incidence, prevalence, and mortality of systemic lupus erythematosus (SLE) in a 6-year period in Taiwan. Patients with international classification of diseases ninth revision (ICD-9) code 710.0 were retrieved from the Taiwanese National Health Insurance Research Database (NHIRD), which covered more than 96 % of the entire population, and from the Ministry of Interior between 2003 and 2008 in Taiwan. Patients with SLE registered as catastrophic illness were enrolled for analysis. The incidence rate, prevalence ratio, and mortality rate stratified by sex and age were analyzed. There were a total of 6,675 SLE patients (5,836 females and 839 in males) during the study period. The average annual incidence rate was 4.87 per 100,000 population, and the average female-to-male incidence ratio was 7.15. The ratio increased with age and peaked at the age of 40-49 years, then decreased thereafter. The incidence rate decreased by 4.2 % per year. The highest incidence rate was noted in the 20-29-year-old age group in females and the 70-79-year-old age group in males. The average prevalence and mortality rates were 97.5 and 1.2 per 100,000 population, respectively. Mortality was 3.2 % in patients diagnosed within 1 year and is more prevalent in young patients with average age of 15.6 years. Incidence rate of SLE has been declining in recent years but the prevalence rate has remained steady. The highest mortality rate is among younger patients diagnosed with SLE within 1 year.
这项基于人群的研究旨在确定台湾地区系统性红斑狼疮（SLE）在 6 年内的发病率、患病率和死亡率趋势。从台湾全民健康保险研究数据库（NHIRD）和内政部 2003 年至 2008 年的国际疾病分类第九版（ICD-9）代码 710.0 中检索到患者。登记为灾难性疾病的 SLE 患者被纳入分析。分析了按性别和年龄分层的发病率、患病率比和死亡率。在研究期间，共有 6675 例 SLE 患者（5836 名女性和 839 名男性）。平均年发病率为每 10 万人 4.87 例，女性与男性的平均发病率比为 7.15。该比值随年龄增长而增加，在 40-49 岁时达到峰值，然后下降。发病率每年下降 4.2%。女性发病率最高的年龄组为 20-29 岁，男性发病率最高的年龄组为 70-79 岁。平均患病率和死亡率分别为每 10 万人 97.5 和 1.2 例。诊断后 1 年内的死亡率为 3.2%，在平均年龄为 15.6 岁的年轻患者中更为常见。近年来 SLE 的发病率呈下降趋势，但患病率保持稳定。在诊断后 1 年内确诊的年轻患者中，死亡率最高。
