Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany.
Pediatr Radiol. 2013 Jun;43(6):716-24. doi: 10.1007/s00247-012-2576-y. Epub 2013 Jan 13.
Gadolinium-enhanced T1-weighted MRI without fat saturation has been recommended for assessment of retinoblastoma.
The purpose of this study was to compare diagnostic image quality without and with fat saturation following gadolinium administration.
High-resolution gadolinium-enhanced T1-weighted sequences with and without fat saturation performed in children with subsequently histopathologically confirmed retinoblastoma were included. Image analysis (image quality [1 = poor, 2 = moderate, 3 = good], anatomical detail depiction, tumour extension) was performed by two neuroradiologists in consensus. Enhancement was scored and measured. Signal- and contrast-to-noise ratios were calculated. Image-assessed tumour invasiveness was compared to histopathological findings. Paired sample t-test was used for statistical analysis.
Thirty-six children (mean age, 19.0 ± 16.8 [SD] months) were included. Image quality and anatomical detail depiction were significantly better without fat saturation (P < 0.001). Tumour enhancement was rated higher with fat saturation (P < 0.001). Fat saturation improved detection of (post-)laminar optic nerve infiltration. Detection of choroidal invasion was improved without fat saturation. Combining both sequences was best in the assessment of tumour extension (sensitivity/specificity for (post-)laminar optic nerve infiltration, 75.0%/100.0%, and for choroidal invasion, 87.5%/85.7%).
Combined T1-weighted spin-echo imaging with and without fat saturation improved the image quality for assessment of invasiveness of retinoblastoma.
钆增强 T1 加权 MRI 无脂肪饱和已被推荐用于视网膜母细胞瘤的评估。
本研究旨在比较钆给药后无脂肪饱和和有脂肪饱和时的诊断图像质量。
纳入经高分辨率钆增强 T1 加权序列（有和无脂肪饱和）证实为随后组织病理学证实的视网膜母细胞瘤患儿。由两位神经放射科医生对图像进行分析（图像质量[1=差，2=中等，3=好]，解剖细节描述，肿瘤延伸）。对增强情况进行评分和测量。计算信号和对比噪声比。将图像评估的肿瘤侵袭性与组织病理学结果进行比较。使用配对样本 t 检验进行统计学分析。
共纳入 36 例患儿（平均年龄 19.0 ± 16.8 [标准差] 个月）。无脂肪饱和时，图像质量和解剖细节显示明显更好（P < 0.001）。脂肪饱和时肿瘤增强评分更高（P < 0.001）。脂肪饱和可提高（术后）神经鞘层视神经浸润的检出率。无脂肪饱和时可提高脉络膜侵犯的检出率。在评估肿瘤延伸方面，两种序列相结合效果最佳（（术后）神经鞘层视神经浸润的敏感性/特异性为 75.0%/100.0%，脉络膜侵犯为 87.5%/85.7%）。
T1 加权自旋回波成像结合有无脂肪饱和均可提高评估视网膜母细胞瘤侵袭性的图像质量。
