人离体小肠和膀胱对猪神经介素U-8的运动反应
Motor response of the human isolated small intestine and urinary bladder to porcine neuromedin U-8.
作者信息
Maggi C A, Patacchini R, Giuliani S, Turini D, Barbanti G, Rovero P, Meli A
机构信息
Pharmacology Department, A. Menarini Pharmaceuticals, Florence, Italy.
出版信息
Br J Pharmacol. 1990 Jan;99(1):186-8. doi: 10.1111/j.1476-5381.1990.tb14675.x.
Abstract
- Porcine neuromedin U-8 produced a concentration (0.3 nM-1 microM)-dependent contraction of the longitudinal muscle of the human isolated ileum, which was unaffected by either atropine (1 microM) or tetrodotoxin (1 microM). 2. By contrast, neuromedin U-8 had only a weak effect on the circular muscle of the human isolated ileum. 3. Neuromedin U-8 also produced a concentration-dependent contraction of mucosa-free muscle strips from the dome of the human isolated urinary bladder, its action being unaffected by either atropine or tetrodotoxin. 4. These findings indicate that neuromedin U-8 exerts a direct contractile effect on smooth muscle of the human intestinal and urinary tract.
摘要
- 猪神经介素U-8对人离体回肠纵行肌产生浓度（0.3 nM - 1 μM）依赖性收缩，该收缩不受阿托品（1 μM）或河豚毒素（1 μM）影响。2. 相比之下，神经介素U-8对人离体回肠环行肌的作用较弱。3. 神经介素U-8对人离体膀胱顶部无黏膜肌条也产生浓度依赖性收缩，其作用不受阿托品或河豚毒素影响。4. 这些发现表明，神经介素U-8对人肠道和泌尿道平滑肌具有直接收缩作用。
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