Maggi C A, Patacchini R, Santicioli P, Giuliani S, Turini D, Barbanti G, Beneforti P, Misuri D, Meli A
Pharmacology Department, Menarini Pharmaceuticals, Florence, Italy.
Eur J Pharmacol. 1988 May 10;149(3):393-5. doi: 10.1016/0014-2999(88)90676-0.
Capsaicin (1 microM) produced a biphasic effect on the motility of longitudinal muscle strips from human jejunum e.g. an initial inhibitory effect on nerve-mediated contractions followed by a delayed increase in motility. Neither effect was observed upon a second application of the drug, indicating desensitization, a proposed marker of the action of capsaicin on sensory nerves. Both substance P and neurokinin A produced a contraction of isolated human jejunum, while calcitonin gene-related peptide had a small and inconsistent inhibitory effect.
辣椒素（1微摩尔）对人空肠纵肌条的运动产生双相效应，例如对神经介导的收缩有初始抑制作用，随后运动延迟增加。再次应用该药物时未观察到任何一种效应，表明脱敏，这是辣椒素对感觉神经作用的一个假定标志。P物质和神经激肽A均使分离的人空肠收缩，而降钙素基因相关肽有微小且不一致的抑制作用。
