III类抗心律失常药物对犬心脏缺血性心肌损伤的影响。
Effects of antiarrhythmic agents classified as class III group on ischaemia-induced myocardial damage in canine hearts.
作者信息
Sano T, Sugiyama S, Taki K, Hanaki Y, Shimada Y, Ozawa T
机构信息
Department of Anesthesiology, Faculty of Medicine, University of Nagoya, Japan.
出版信息
Br J Pharmacol. 1990 Mar;99(3):577-81. doi: 10.1111/j.1476-5381.1990.tb12971.x.
Abstract
- The cardioprotective effects of antiarrhythmic agents classified as class III, amiodarone, sotalol and E-4031, were investigated in anaesthetized dogs. 2. The left anterior descending coronary artery was occluded for 2 h. 3. Heart mitochondria were prepared from both the ischaemic and non-ischaemic areas, and their function was estimated polarographically. 4. Activities of the lysosomal enzymes, N-acetyl-beta-glucosaminidase and beta-glucuronidase, were measured in each fraction. 5. Two hour occlusion induced ventricular arrhythmias, and amiodarone, sotalol and E-4031 greatly suppressed the development of arrhythmias. 6. Amiodarone, sotalol and E-4031 significantly protected mitochondria against ischaemia, and prevented ischaemia-induced leakage of lysosomal enzymes. 7. Antiarrhythmic agents classified as class III show cardioprotective effects, which might participate in their antiarrhythmic effect.
摘要
- 研究了Ⅲ类抗心律失常药物胺碘酮、索他洛尔和E-4031对麻醉犬的心脏保护作用。2. 左冠状动脉前降支闭塞2小时。3. 从缺血区和非缺血区制备心脏线粒体，并用极谱法评估其功能。4. 测量各组分中溶酶体酶N-乙酰-β-氨基葡萄糖苷酶和β-葡萄糖醛酸酶的活性。5. 两小时的闭塞诱发室性心律失常，胺碘酮、索他洛尔和E-4031能显著抑制心律失常的发生。6. 胺碘酮、索他洛尔和E-4031能显著保护线粒体免受缺血损伤，并防止缺血诱导的溶酶体酶泄漏。7. Ⅲ类抗心律失常药物具有心脏保护作用，这可能参与了它们的抗心律失常作用。
相似文献
1
Effects of antiarrhythmic agents classified as class III group on ischaemia-induced myocardial damage in canine hearts.III类抗心律失常药物对犬心脏缺血性心肌损伤的影响。
Br J Pharmacol. 1990 Mar;99(3):577-81. doi: 10.1111/j.1476-5381.1990.tb12971.x.
2
Cardioprotective effects of various class I antiarrhythmic drugs in canine hearts.各类I类抗心律失常药物对犬心脏的心脏保护作用。
J Am Coll Cardiol. 1989 Jul;14(1):219-24. doi: 10.1016/0735-1097(89)90077-6.
3
Cardioprotective effect of bepridil on ischemic myocardial damages in dogs.苄普地尔对犬缺血性心肌损伤的心脏保护作用。
Arch Int Pharmacodyn Ther. 1989 May-Jun;299:221-31.
4
Biochemical and antiarrhythmic effects of three calcium channel antagonists in ischemic canine hearts.三种钙通道拮抗剂对缺血犬心脏的生化及抗心律失常作用
Clin Ther. 1989 Jul-Aug;11(4):461-71.
5
Cardioprotective and antiarrhythmic effects of beta-blockers, propranolol, bisoprolol, and nipradilol in a canine model of regional ischemia.β受体阻滞剂、普萘洛尔、比索洛尔和尼普地洛在犬局部缺血模型中的心脏保护和抗心律失常作用
Heart Vessels. 1989;5(1):10-6. doi: 10.1007/BF02058353.
6
The effect of cibenzoline on myocardial damages in dogs.昔苯唑啉对犬心肌损伤的影响。
Arzneimittelforschung. 1989 Mar;39(3):325-8.
7
Prostaglandin I2 analogue and propranolol prevent ischaemia induced mitochondrial dysfunction through the stabilisation of lysosomal membranes.前列环素I2类似物和普萘洛尔通过稳定溶酶体膜来预防缺血诱导的线粒体功能障碍。
Cardiovasc Res. 1988 Mar;22(3):219-25. doi: 10.1093/cvr/22.3.219.
8
Hemodynamic effects of antiarrhythmic compounds: intrinsic effects and autonomic modulation.抗心律失常化合物的血流动力学效应：内在效应与自主神经调节
Am J Cardiol. 1997 Oct 23;80(8A):24G-30G. doi: 10.1016/s0002-9149(97)00711-x.
9
Biochemical and morphological changes in myocardium during coronary occlusion and reperfusion in canine hearts: effects of propranolol on myocardial damage.犬心冠状动脉闭塞及再灌注期间心肌的生化和形态学变化：普萘洛尔对心肌损伤的影响
Cardiovasc Res. 1989 May;23(5):417-23. doi: 10.1093/cvr/23.5.417.
10
The cardioprotective effect of gamma-glutamylcysteine ethyl ester during coronary reperfusion in canine hearts.γ-谷氨酰半胱氨酸乙酯在犬心脏冠脉再灌注期间的心脏保护作用。
Br J Pharmacol. 1991 Dec;104(4):805-10. doi: 10.1111/j.1476-5381.1991.tb12510.x.
引用本文的文献
1
Mitochondrial and Sarcoplasmic Reticulum Interconnection in Cardiac Arrhythmia.线粒体与肌浆网在心律失常中的相互联系
Front Cell Dev Biol. 2021 Jan 28;8:623381. doi: 10.3389/fcell.2020.623381. eCollection 2020.
2
Prevailing Effects of Ibutilide on Fast Delayed Rectifier K Channel.伊布利特对快速延迟整流钾通道的普遍影响。
J Membr Biol. 2019 Dec;252(6):609-616. doi: 10.1007/s00232-019-00098-x. Epub 2019 Oct 4.
3
Sotalol. An updated review of its pharmacological properties and therapeutic use in cardiac arrhythmias.索他洛尔。其药理特性及在心律失常治疗应用中的最新综述。
Drugs. 1993 Oct;46(4):678-719. doi: 10.2165/00003495-199346040-00007.
4
The cardioprotective effect of gamma-glutamylcysteine ethyl ester during coronary reperfusion in canine hearts.γ-谷氨酰半胱氨酸乙酯在犬心脏冠脉再灌注期间的心脏保护作用。
Br J Pharmacol. 1991 Dec;104(4):805-10. doi: 10.1111/j.1476-5381.1991.tb12510.x.
5
The effects of a high dose of ascorbate on ischemia-reperfusion-induced mitochondrial dysfunction in canine hearts.高剂量抗坏血酸盐对犬心脏缺血再灌注诱导的线粒体功能障碍的影响。
Heart Vessels. 1992;7(1):18-23. doi: 10.1007/BF01745863.
6
Amiodarone. An overview of its pharmacological properties, and review of its therapeutic use in cardiac arrhythmias.胺碘酮。其药理特性概述及其在心律失常治疗中的应用综述。
Drugs. 1992 Jan;43(1):69-110. doi: 10.2165/00003495-199243010-00007.
本文引用的文献
1
Recovery time course of ventricular vulnerability after coronary reperfusion in relation to mitochondrial function in ischemic myocardium.冠状动脉再灌注后心室易损性的恢复时间进程与缺血心肌线粒体功能的关系
Am Heart J. 1980 Dec;100(6 Pt 1):829-37. doi: 10.1016/0002-8703(80)90063-0.
2
Clinical pharmacology and therapeutic applications of the antiarrhythmic agent amiodarone.抗心律失常药物胺碘酮的临床药理学及治疗应用
Am Heart J. 1981 Apr;101(4):480-93. doi: 10.1016/0002-8703(81)90140-x.
3
New perspectives in the pharmacologic therapy of cardiac arrhythmias.心律失常药物治疗的新视角。
Prog Cardiovasc Dis. 1980 Jan-Feb;22(4):243-301. doi: 10.1016/0033-0620(80)90011-0.
4
The effects of verapamil on mitochondrial dysfunction associated with coronary reperfusion.维拉帕米对与冠状动脉再灌注相关的线粒体功能障碍的影响。
Jpn Circ J. 1983 Jul;47(7):830-6. doi: 10.1253/jcj.47.830.
5
A comparison of the electrophysiologic effects of intravenous and oral amiodarone in the same patient.同一患者静脉注射与口服胺碘酮的电生理效应比较。
Circulation. 1984 Jan;69(1):120-4. doi: 10.1161/01.cir.69.1.120.
6
7
Action of sotalol on potential reentrant pathways and ventricular tachyarrhythmias in conscious dogs in the late postmyocardial infarction phase.索他洛尔对心肌梗死后晚期清醒犬潜在折返通路及室性快速心律失常的作用。
Circulation. 1983 Oct;68(4):865-71. doi: 10.1161/01.cir.68.4.865.
8
The effects of beta-blocking agents on mitochondrial function in ischemic myocardium.β受体阻滞剂对缺血心肌线粒体功能的影响。
Jpn Circ J. 1984 Jan;48(1):32-6. doi: 10.1253/jcj.48.32.
9
Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone.胺碘酮对豚鼠乳头肌中失活钠通道及去极化诱导的自律性的阻滞作用。
Circ Res. 1984 Sep;55(3):278-85. doi: 10.1161/01.res.55.3.278.
10
Reduction by hyaluronidase of myocardial necrosis following coronary artery occlusion.透明质酸酶减轻冠状动脉闭塞后心肌坏死
Circulation. 1972 Sep;46(3):430-7. doi: 10.1161/01.cir.46.3.430.
Zotero 插件