Department of Toxicology, Erciyes University, Faculty of Pharmacy, Kayseri, Turkey.
J Biochem Mol Toxicol. 2013 Mar;27(3):213-8. doi: 10.1002/jbt.21472. Epub 2013 Jan 11.
Manganese superoxide dismutase (MnSOD) is the most effective antioxidant enzyme in mitochondria and protects cells from reactive oxygen species-induced oxidative damage. The aim of this study was to investigate the association between MnSOD Ala-9 Val gene polymorphism and prostate cancer (PCa) risk in Turkish men with prostate cancer. 33 patients with PCa and 81 control individuals were included in the study. We observed an association between MnSOD Ala/Ala frequency and a higher PCa risk. In addition, we found that the increased risk of early-onset PCa (under age of 65) in the men homozygous for Ala allele was higher than the men homozygous for Val allele. However, we determined that MnSOD Ala-9 Val genotype was not associated with the aggressiveness of the disease. The results of our study suggest that MnSOD Ala/Ala genotype may influence on early-onset of PCa patients, but no effect on subsequent development of the disease in Turkish men. However, our study has a limitation that is small numbers of individuals for cases and controls. Therefore, the presented study limited our statistical power to fully investigate the gene polymorphism on cancer risk.
锰超氧化物歧化酶（MnSOD）是线粒体中最有效的抗氧化酶，可保护细胞免受活性氧诱导的氧化损伤。本研究旨在探讨土耳其前列腺癌（PCa）患者 MnSOD Ala-9 Val 基因多态性与 PCa 风险的关系。本研究纳入了 33 例 PCa 患者和 81 例对照组。我们观察到 MnSOD Ala/Ala 频率与较高的 PCa 风险之间存在关联。此外，我们发现 Ala 等位基因纯合子的男性发生早发性 PCa（65 岁以下）的风险高于 Val 等位基因纯合子的男性。然而，我们发现 MnSOD Ala-9 Val 基因型与疾病的侵袭性无关。我们的研究结果表明，MnSOD Ala/Ala 基因型可能影响土耳其男性早发性 PCa 患者的发病，但对疾病的后续发展没有影响。然而，我们的研究存在一个局限性，即病例和对照组的个体数量较少。因此，本研究限制了我们的统计能力，无法充分研究基因多态性对癌症风险的影响。
