Department of Urology, Istanbul University, Istanbul, Turkey.
BJU Int. 2013 Aug;112(4):E406-14. doi: 10.1111/bju.12176. Epub 2013 Jun 14.
To evaluate the relationship between manganese superoxide dismutase (MnSOD) Ile58Thr, catalase (CAT) C-262T and myeloperoxidase (MPO) G-463A gene polymorphisms and the susceptibility and clinicopathological characteristics of prostate cancer.
In all, 155 patients diagnosed with prostate cancer and 195 controls with negative digital rectal examinations and PSA levels of <4 ng/dL were enrolled in this study. MnSOD, CAT and MPO gene polymorphisms were identified by polymerase chain reaction restriction-fragment length polymorphism methods.
The TT genotype in MnSOD Ile58Thr polymorphism, CC genotype in the CAT C-262T polymorphism and the GG genotype in the MPO G-463A polymorphism were the predominant genotypes amongst this Turkish male population. There was no association between MnSOD Ile58Thr polymorphism and prostate cancer. For the CAT C-262T polymorphism, the TT genotype had significantly increased prostate cancer risk compared with the CC genotype. Similarly, the TT genotype had a 1.94- and 3.83-fold increased risk for high-stage disease and metastasis, respectively, when compared with the CC genotype. For the MPO G-463A polymorphism, the GG genotype had 1.78-fold increased risk of prostate cancer compared with the AA genotype. However, no association was found regarding Gleason score, advanced and metastatic prostate cancer risk.
It seems that there is no association of prostate cancer with MnSOD Ile58Thr polymorphism, whereas the TT genotype in the CAT C-262T polymorphism and the GG genotype in the MPO G-463A polymorphism may be associated with increased prostate cancer risk. The TT genotype in the CAT C-262T gene polymorphism may also be a risk factor in tumour progression and metastasis among Turkish men.
评估锰超氧化物歧化酶（MnSOD）Ile58Thr、过氧化氢酶（CAT）C-262T 和髓过氧化物酶（MPO）G-463A 基因多态性与前列腺癌易感性及临床病理特征的关系。
本研究共纳入 155 例经诊断患有前列腺癌的患者和 195 例经数字直肠检查和 PSA 水平<4ng/dL 检测为阴性的对照者。采用聚合酶链反应-限制性片段长度多态性方法鉴定 MnSOD、CAT 和 MPO 基因多态性。
在该土耳其男性人群中，MnSOD Ile58Thr 多态性的 TT 基因型、CAT C-262T 多态性的 CC 基因型和 MPO G-463A 多态性的 GG 基因型是主要的基因型。MnSOD Ile58Thr 多态性与前列腺癌之间无关联。对于 CAT C-262T 多态性，与 CC 基因型相比，TT 基因型显著增加了前列腺癌的风险。同样，与 CC 基因型相比，TT 基因型发生高分期疾病和转移的风险分别增加了 1.94 倍和 3.83 倍。对于 MPO G-463A 多态性，与 AA 基因型相比，GG 基因型患前列腺癌的风险增加了 1.78 倍。然而，在 Gleason 评分、晚期和转移性前列腺癌风险方面没有发现关联。
似乎前列腺癌与 MnSOD Ile58Thr 多态性无关，而 CAT C-262T 多态性的 TT 基因型和 MPO G-463A 多态性的 GG 基因型可能与前列腺癌风险增加相关。CAT C-262T 基因多态性的 TT 基因型也可能是土耳其男性肿瘤进展和转移的危险因素。
