受体寡聚化：从 B 类 G 蛋白偶联受体的早期证据到当前认识。
Receptor oligomerization: from early evidence to current understanding in class B GPCRs.
机构信息
Endocrinology, School of Biological Sciences, The University of Hong Kong Hong Kong, China.
出版信息
Front Endocrinol (Lausanne). 2013 Jan 4;3:175. doi: 10.3389/fendo.2012.00175. eCollection 2012.
Abstract
Dimerization or oligomerization of G protein-coupled receptors (GPCRs) are known to modulate receptor functions in terms of ontogeny, ligand-oriented regulation, pharmacological diversity, signal transduction, and internalization. Class B GPCRs are receptors to a family of hormones including secretin, growth hormone-releasing hormone, vasoactive intestinal polypeptide and parathyroid hormone, among others. The functional implications of receptor dimerization have extensively been studied in class A GPCRs, while less is known regarding its function in class B GPCRs. This article reviews receptor oligomerization in terms of the early evidence and current understanding particularly of class B GPCRs.
摘要
G 蛋白偶联受体（GPCRs）的二聚化或寡聚化已知可调节受体的功能，包括个体发生、配体定向调节、药理学多样性、信号转导和内化。B 类 GPCR 是包括分泌素、生长激素释放激素、血管活性肠肽和甲状旁腺激素等多种激素的受体。A 类 GPCR 中二聚体的功能意义已经得到了广泛研究，而 B 类 GPCR 中二聚体的功能则知之甚少。本文综述了 B 类 GPCR 中二聚体的早期证据和目前的理解。
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