Sung Cecilia Ying Ju, Lee Nikki Pui-Yue, El-Nezami Hani
School of Biological Sciences, Faculty of Sciences, Kadoorie Biological Sciences Building, The University of Hong Kong, Pokfulam, Hong Kong.
Int J Hepatol. 2012;2012:439024. doi: 10.1155/2012/439024. Epub 2012 Dec 17.
T helper 17 (T(H)17) is a novel subset of T helper cells that has recently been identified in the hepatocellular carcinoma (HCC) tumor environment. Its presence seems to be linked with HCC progression, possibly via facilitating angiogenesis. The origin of tumor-associated T(H)17 may be related to the gut, in which the differentiation of T cells, especially T(H)17 cells, is affected by microbiota. As T(H)17 may appear to be a new therapeutic target against tumor-promoting inflammation, strategies such as using probiotics to polarize the response away from T(H)17 may be beneficial to slow down tumor progression. This paper will attempt to discuss the potential linkage between HCC progression, T(H)17, and gut microbiota and the possible therapeutic implications of probiotics to modulate T(H)17-mediated response for tumor growth.
辅助性T细胞17（Th17）是一种新型的辅助性T细胞亚群，最近在肝细胞癌（HCC）肿瘤环境中被发现。它的存在似乎与HCC进展有关，可能是通过促进血管生成。肿瘤相关Th17的来源可能与肠道有关，其中T细胞，尤其是Th17细胞的分化受微生物群影响。由于Th17似乎可能是对抗肿瘤促进炎症的新治疗靶点，使用益生菌使反应偏离Th17等策略可能有利于减缓肿瘤进展。本文将试图探讨HCC进展、Th17和肠道微生物群之间的潜在联系，以及益生菌调节Th17介导的肿瘤生长反应的可能治疗意义。
