Tian Guo-Ping, Chen Wu-Jun, He Ping-Ping, Yin Wei-Dong, Tnag Chao-Ke
Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, University of South China, Hengyang 421001, China.
Sheng Li Ke Xue Jin Zhan. 2012 Oct;43(5):345-50.
Lipoprotein lipase (LPL) which is the rate-limiting enzyme for the hydrolysis of the triglyceride (TG) core of circulating TG-rich lipoproteins, chylomicrons, low-density lipoproteins (LDL) and very low-density lipoproteins (VLDL) play an important role in reducing TG deposition in vivo. Recent advances indicate that LPL gene structure, synthesis, secretion and degradation had complexity, and it is regulated by many transcription factors, miRNA, interactive proteins and hormonal. Its role in atherosclerosis in the current studies is still controversial. So we focus the LPL on the structure, synthesis and degradation, function, regulation and contribution to atherosclerosis to clarify its role in cardiovascular disease (CVD).
脂蛋白脂肪酶（LPL）是循环中富含甘油三酯（TG）的脂蛋白、乳糜微粒、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）核心TG水解的限速酶，在减少体内TG沉积方面发挥着重要作用。最近的进展表明，LPL基因的结构、合成、分泌和降解具有复杂性，并且受到多种转录因子、微小RNA、相互作用蛋白和激素的调节。在当前研究中，其在动脉粥样硬化中的作用仍存在争议。因此，我们聚焦于LPL的结构、合成与降解、功能、调节及其对动脉粥样硬化的影响，以阐明其在心血管疾病（CVD）中的作用。
