Queensland Lung Transplant Service, The Prince Charles Hospital, Brisbane, Queensland, Australia.
Respirology. 2013 Apr;18(3):397-411. doi: 10.1111/resp.12050.
Mesenchymal stem cells (MSC) are a population of tissue-resident adult progenitor cells that were originally identified in bone marrow, but have now been identified in many organs including the lung. Although their precise role in organ function remains incompletely defined, mounting evidence suggests that they are an important component of the parenchymal progenitor cell niche and orchestrate organ homeostasis and repair following injury. In this review, what is known about MSC biology will be outlined with particular emphasis on lung biology, and the therapeutic potential of MSC-based cell therapy will also be highlighted.
间充质干细胞（MSC）是一种组织驻留的成体祖细胞群体，最初在骨髓中被鉴定出来，但现在已在许多器官中被鉴定出来，包括肺。尽管它们在器官功能中的确切作用仍不完全确定，但越来越多的证据表明，它们是实质祖细胞龛的重要组成部分，并在损伤后协调器官的稳态和修复。在这篇综述中，将概述 MSC 生物学的已知内容，特别强调肺生物学，并且还将突出基于 MSC 的细胞治疗的治疗潜力。
