Trauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Int J Mol Med. 2024 Nov;54(5). doi: 10.3892/ijmm.2024.5416. Epub 2024 Sep 2.
Sepsis‑induced myopathy (SIM) is one of the leading causes of death in critically ill patients. SIM mainly involves the respiratory and skeletal muscles of patients, resulting in an increased risk of lung infection, aggravated respiratory failure, and prolonged mechanical ventilation and hospital stay. SIM is also an independent risk factor associated with increased mortality in critically ill patients. At present, no effective treatment for SIM has yet been established. However, mesenchymal stem cells (MSCs) have emerged as a promising therapeutic approach and have been utilized in the treatment of various clinical conditions. A significant body of basic and clinical research supports the efficacy of MSCs in managing sepsis and muscle‑related diseases. This literature review aims to explore the relationship between MSCs and sepsis, as well as their impact on skeletal muscle‑associated diseases. Additionally, the present review discusses the potential mechanisms and therapeutic benefits of MSCs in the context of SIM.
脓毒症性肌病（SIM）是危重病患者死亡的主要原因之一。SIM 主要涉及患者的呼吸肌和骨骼肌，导致肺部感染风险增加、呼吸衰竭加重以及机械通气和住院时间延长。SIM 也是与危重病患者死亡率增加相关的独立危险因素。目前，尚未确立针对 SIM 的有效治疗方法。然而，间充质干细胞（MSCs）已成为一种有前途的治疗方法，并已应用于各种临床病症的治疗中。大量基础和临床研究支持 MSCs 在管理脓毒症和与肌肉相关疾病方面的疗效。本文综述旨在探讨 MSCs 与脓毒症之间的关系，以及它们对与骨骼肌相关疾病的影响。此外，本综述还讨论了 MSCs 在 SIM 背景下的潜在机制和治疗益处。
