Rege-Cambrin G, Kerim S, Scaravaglio P, Michaux J L, Van den Berghe H, Saglio G
Dipartimento di Scienze Biomediche e Oncologia Umana, Università di Torino, Italy.
Cancer Genet Cytogenet. 1990 May;46(1):99-106. doi: 10.1016/0165-4608(90)90015-3.
We report two cases of monocytic leukemia associated with cytogenetic changes involving the juxtacentromeric heterochromatin of different chromosomes. In a patient with chronic myelomonocytic leukemia (CMMoL) we describe a translocation t(1;9)(q12;q13) in which the duplicated derivative chromosome 9q + showed a huge centromeric C-band, derived by fusion of the heterochromatic regions of chromosomes 1 and 9. The constitutional karyotype showed two heterochromatin polymorphisms, 1qh + and inv(9qh). In the second case, an acute monoblastic leukemia was associated with an abnormally elongated juxtacentromeric heterochromatic region of chromosome 4 that was not constitutionally present.
我们报告了两例与涉及不同染色体近着丝粒异染色质的细胞遗传学改变相关的单核细胞白血病病例。在一名慢性粒单核细胞白血病（CMMoL）患者中，我们描述了一种t(1;9)(q12;q13)易位，其中重复的衍生染色体9q +显示出巨大的着丝粒C带，这是由染色体1和9的异染色质区域融合形成的。该患者的染色体组型显示出两种异染色质多态性，即1qh +和inv(9qh)。在第二例病例中，急性单核细胞白血病与染色体4异常伸长的近着丝粒异染色质区域相关，该区域在患者的染色体组型中原本并不存在。
