慢性粒细胞白血病（CML）中6号染色体长臂的染色体异常。

Chromosomal anomaly of 6q in chronic myelogenous leukemia (CML).

作者信息

Srivastava A K, Gruppo R A, Siegrist C W

出版信息

Cancer Genet Cytogenet. 1981 Mar;3(2):131-6. doi: 10.1016/0165-4608(81)90067-4.

Abstract

Anomalies of chromosome 6q, along with other chromosomal anomalies, are described in the bone marrow cells of two patients with chronic myelogenous leukemia (CML). One patient a 14-year-old male, developed the karyotype 46,XY,t(1;6)(p36;q15),del(3)(q25), del(17)(p11),? inv(17)(q12q24) during blastic crisis of his disease. The other patient, a 24-year-old male, had the karyotype 46,XY,del(6)(q13),5(9;22)(q34;q11) during the early phase of his disease and evolution of i(17q) in the karyotype late in the disease.

摘要

在两名慢性粒细胞白血病（CML）患者的骨髓细胞中，发现了6号染色体长臂异常以及其他染色体异常情况。其中一名患者为14岁男性，在疾病的急变期出现了核型46,XY,t(1;6)(p36;q15),del(3)(q25), del(17)(p11),? inv(17)(q12q24)。另一名患者为24岁男性，在疾病早期的核型为46,XY,del(6)(q13),5(9;22)(q34;q11)，疾病后期核型演变为i(17q)。