Margolin S G, Breneman J C, Denman D L, LaChapelle P, Weckbach L, Aron B S
Barrett Clinical Center for Cancer Prevention, Treatment and Research, University of Cincinnati Medical Center, Ohio 45267-0757.
Cancer Nurs. 1990 Apr;13(2):71-80.
Moist skin desquamation has been of concern to radiation oncologists, nurses and patients since the inception of this mode of therapy. As radiation treatment machines became more sophisticated, severe reactions became less of a problem. However, with the increasing use of chemotherapy and radiation as combined modalities, moist skin reaction is occurring with greater frequency. A noncomparative study of 20 patients using a hydrocolloid occlusive dressing (Duoderm) was initiated. The purpose of the study was to determine whether moist occlusive healing would be beneficial. The dressing was evaluated on the basis of healing time, safety, wound temperature, bacterial growth, and comfort. Data were collected using photographs, bacterial cultures, temperature probes, and patient evaluations. Eighteen patients completed the study. All patients' skin reactions healed. There were no wound infections evident. Mean healing time was 12 days, with mean wound temperature relative to body core -0.8 degree C on day 1 and -1.2 degrees C on the healed site. Patient results on comfort were: 8 of 18 excellent, 7 of 18 good, 3 of 18 fair, and 0 of 18 poor. The results of this study indicate that a hydrocolloid occlusive dressing can be effective in the healing process of moist skin reaction that is due to radiation therapy.
自这种治疗方式开始以来，湿性皮肤脱屑一直是放射肿瘤学家、护士和患者关注的问题。随着放射治疗设备变得更加先进，严重反应已不再是一个大问题。然而，随着化疗和放疗联合应用的增加，湿性皮肤反应的发生频率更高。启动了一项对20名患者使用水胶体封闭敷料（Duoderm）的非对照研究。该研究的目的是确定湿性封闭愈合是否有益。根据愈合时间、安全性、伤口温度、细菌生长和舒适度对敷料进行评估。使用照片、细菌培养、温度探头和患者评估收集数据。18名患者完成了研究。所有患者的皮肤反应均愈合。没有明显的伤口感染。平均愈合时间为12天，第1天伤口平均温度相对于体核为-0.8摄氏度，愈合部位为-1.2摄氏度。患者的舒适度结果为：18人中有8人优秀，7人良好，3人中等，18人中有0人差。这项研究的结果表明，水胶体封闭敷料在放疗引起的湿性皮肤反应的愈合过程中可能是有效的。
