Pan Xiong-Fei, Xie Yao, Loh Marie, Yang Shu-Juan, Wen Yuan-Yuan, Tian Zhi, Huang He, Lan Hui, Chen Feng, Soong Richie, Yang Chun-Xia
Department of Epidemiology, West China School of Public Health, Sichuan University, Chengdu, China.
Asian Pac J Cancer Prev. 2012;13(11):5637-42. doi: 10.7314/apjcp.2012.13.11.5637.
Gastric cancer (GC) is one of the most common malignancies and its mortality ranks third among all cancers in China. We previously noted that XRCC1 Arg194Trp was associated with GC risk in Western China in a study on XRCC1 Arg194Trp and ADPRT Val762Ala. We aimed to further explore the association of these polymorphisms with risk of the noncardia subtype.
We enrolled 176 noncardia GC patients and 308 controls from four hospitals and a community between October 2010 and August 2011. Genotyping was performed in a 384-well plate format on the Sequenom MassARRAY platform. A self-designed questionnaire was utilized to collect epidemiological data from the subjects regarding demographic factors and potential risk factors.
Subjects were aged 56.8±11.8 (mean±standard deviation) and 57.6±11.1 years in the case and control groups, respectively. Individuals carrying the XRCC1 Trp/Trp or Arg/Trp variant genotype were at significantly increased risk of noncardia GC (adjusted OR, 1.48; 95% CI, 1.00-2.17), after adjustment for family history of cancer, drinking, and smoking. The increased risk of XRCC1 Arg194Trp variant genotype was more pronounced among subjects below 60 years old (adjusted OR, 1.78; 95% CI, 1.07-2.96), compared to older individuals. ADPRT Val762Ala variants (Ala/Ala or Val/Ala) were not associated with noncardia GC (adjusted OR, 1.03; 95% CI, 0.69-1.54).
Our study suggests that XRCC1 Arg194Trp is a genetic susceptibility factor for developing noncardia GC in Han Chinese in Western China. In particular, individuals with the XRCC1 Arg194Trp variant genotype are at increased risk for GC below 60 years old.
胃癌（GC）是最常见的恶性肿瘤之一，在中国所有癌症中其死亡率排名第三。我们之前在一项关于XRCC1 Arg194Trp和ADPRT Val762Ala的研究中发现，XRCC1 Arg194Trp与中国西部的胃癌风险相关。我们旨在进一步探讨这些多态性与非贲门亚型风险的关联。
2010年10月至2011年8月期间，我们从四家医院和一个社区招募了176例非贲门胃癌患者和308名对照。在Sequenom MassARRAY平台上以384孔板形式进行基因分型。使用自行设计的问卷从受试者收集关于人口统计学因素和潜在风险因素的流行病学数据。
病例组和对照组受试者的年龄分别为56.8±11.8（均值±标准差）岁和57.6±11.1岁。在调整癌症家族史、饮酒和吸烟因素后，携带XRCC1 Trp/Trp或Arg/Trp变异基因型的个体患非贲门胃癌的风险显著增加（调整后的比值比，1.48；95%置信区间，1.00 - 2.17）。与年龄较大的个体相比，XRCC1 Arg194Trp变异基因型增加的风险在60岁以下的受试者中更为明显（调整后的比值比，1.78；95%置信区间，1.07 - 2.96）。ADPRT Val762Ala变异（Ala/Ala或Val/Ala）与非贲门胃癌无关（调整后的比值比，1.03；95%置信区间，0.69 - 1.54）。
我们的研究表明，XRCC1 Arg194Trp是中国西部汉族人群发生非贲门胃癌的遗传易感因素。特别是，携带XRCC1 Arg194Trp变异基因型的个体在60岁以下患胃癌的风险增加。
