Department of Clinical Laboratory, 66352Xijing Hospital, Fourth Military Medical University, Xian, Shaanxi, China.
J Int Med Res. 2021 Mar;49(3):300060521992956. doi: 10.1177/0300060521992956.
To investigate the association between poly(ADP-ribose) polymerase 1 () rs1136410 Val762Ala and cancer risk in Asian populations, as published findings remain controversial.
The PubMed and EMBASE databases were searched, and references of identified studies and reviews were screened, to find relevant studies. Meta-analyses were performed to evaluate the association between rs1136410 Val762Ala and cancer risk, reported as odds ratio (OR) and 95% confidence interval (CI).
A total of 24 studies with 8 926 cases and 15 295 controls were included. Overall, a significant association was found between rs1136410 Val762Ala and cancer risk in East Asians (homozygous: OR 1.19, 95% CI 1.06, 1.35; heterozygous: OR 1.10, 95% CI 1.04, 1.17; recessive: OR 1.13, 95% CI 1.02, 1.25; dominant: OR 1.13, 95% CI 1.06, 1.19; and allele comparison: OR 1.09, 95% CI 1.03, 1.15). Stratification analyses by race and cancer type revealed similar results for gastric cancer among the Chinese population.
The findings suggest that rs1136410 Val762Ala may be significantly associated with an increased cancer risk in Asians, particularly the Chinese population.
探讨亚洲人群聚（ADP-核糖）聚合酶 1（PARP1）rs1136410 缬氨酸 762 丙氨酸（Val762Ala）与癌症风险的关联，因为已发表的研究结果存在争议。
检索 PubMed 和 EMBASE 数据库，并筛选已确定研究和综述的参考文献，以找到相关研究。进行荟萃分析以评估 rs1136410 Val762Ala 与癌症风险之间的关联，报告为比值比（OR）和 95%置信区间（CI）。
共纳入 24 项研究，包括 8926 例病例和 15295 例对照。总体而言，rs1136410 Val762Ala 与东亚人群的癌症风险存在显著关联（纯合子：OR 1.19，95%CI 1.06，1.35；杂合子：OR 1.10，95%CI 1.04，1.17；隐性：OR 1.13，95%CI 1.02，1.25；显性：OR 1.13，95%CI 1.06，1.19；和等位基因比较：OR 1.09，95%CI 1.03，1.15）。按种族和癌症类型进行分层分析显示，中国人群的胃癌也存在类似结果。
研究结果表明，rs1136410 Val762Ala 可能与亚洲人群，特别是中国人群的癌症风险显著相关。
