Rezaianzadeh Abbas, Talei Abdolrasoul, Rajaeefard Abdereza, Hasanzadeh Jafar, Tabatabai Hamidreza, Tahmasebi Sedigheh, Mousavizadeh Ali
Research Center for Health Sciences, Department of Epidemiology, School of Health and Nutrition, Shiraz University of Medical Sciences, shiraz, Iran.
Asian Pac J Cancer Prev. 2012;13(11):5767-72. doi: 10.7314/apjcp.2012.13.11.5767.
Identification of simple and measurable prognostic factors is an important issue in treatment evaluation of breast cancer. The present study was conducted to evaluate the prognostic role of vascular invasion in lymph node negative breast cancer patients.
in a retrospective design, we analyzed the recorded profiles of the 1,640 patients treated in the breast cancer department of Motahari clinic affiliated to Shiraz University of Medical Sciences, Shiraz, Iran, from January 1999 to December 2012. Overall and adjusted survivals were evaluated by the Cox proportional hazard model. All the hypotheses were considered two-sided and a p-value of 0.05 or less was considered as statistically significant.
Mean age in lymph node negative and positive patients was 50.0 and 49.8 respectively. In lymph node negative patients, the number of nodes, tumor size, lymphatic invasion, vascular invasion, progesterone receptor, and nuclear grade were significant predictors. In lymph node and lymphatic negative patients, vascular invasion also played a significant prognostic role in the survival which was not evident in lymph node negative patients with lymphatic invasion.
The results of our large cohort study, with long term follow up and using multivariate Cox proportional model and comparative design showed a significant prognostic role of vascular invasion in early breast cancer patients. Vascular invasion as an independent prognostic factor in lymph node negative invasive breast cancer.
识别简单且可测量的预后因素是乳腺癌治疗评估中的一个重要问题。本研究旨在评估血管侵犯在淋巴结阴性乳腺癌患者中的预后作用。
采用回顾性设计，我们分析了1999年1月至2012年12月在伊朗设拉子医科大学附属莫塔哈里诊所乳腺癌科接受治疗的1640例患者的记录资料。通过Cox比例风险模型评估总生存率和校正生存率。所有假设均采用双侧检验，p值小于或等于0.05被认为具有统计学意义。
淋巴结阴性和阳性患者的平均年龄分别为50.0岁和49.8岁。在淋巴结阴性患者中，淋巴结数量、肿瘤大小、淋巴管侵犯、血管侵犯、孕激素受体和核分级是显著的预后预测因素。在淋巴结和淋巴管均为阴性的患者中，血管侵犯在生存方面也具有显著的预后作用，而在伴有淋巴管侵犯的淋巴结阴性患者中并不明显。
我们这项大型队列研究的结果，经过长期随访并使用多变量Cox比例模型和对比设计，显示血管侵犯在早期乳腺癌患者中具有显著的预后作用。血管侵犯是淋巴结阴性浸润性乳腺癌的一个独立预后因素。
