MRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Division of Medical Microbiology, Faculty of Health Sciences , University of Cape Town .
Crit Rev Microbiol. 2014 Feb;40(1):18-29. doi: 10.3109/1040841X.2012.749211. Epub 2013 Jan 15.
Mycobacterium tuberculosis (Mtb) and other members of the Mtb complex possess an expanded complement of genes for the biosynthesis of molybdenum cofactor (MoCo), a tricyclic pterin molecule that is covalently attached to molybdate. This cofactor allows the redox properties of molybdenum to be harnessed by enzymes in order to catalyze redox reactions in carbon, nitrogen and sulfur metabolism. In this article, we summarize recent advances in elucidating the MoCo biosynthetic pathway in Mtb and highlight the evidence implicating the biosynthesis of this cofactor, as well as the enzymes that depend upon it for activity, in Mtb pathogenesis.
结核分枝杆菌（Mtb）和 Mtb 复合体的其他成员拥有用于合成钼辅因子（MoCo）的大量基因，钼辅因子是一种三环蝶啶分子，与钼酸盐共价结合。这种辅因子使钼的氧化还原性质能够被酶利用，从而催化碳、氮和硫代谢中的氧化还原反应。在本文中，我们总结了阐明 Mtb 中 MoCo 生物合成途径的最新进展，并强调了该辅因子的生物合成以及依赖其活性的酶在 Mtb 发病机制中的作用的证据。
