Department of Plant Biology, Braunschweig University of Technology, 38106 Braunschweig, Germany.
J Biol Chem. 2013 May 10;288(19):13165-72. doi: 10.1074/jbc.R113.455311. Epub 2013 Mar 28.
The transition element molybdenum needs to be complexed by a special cofactor to gain catalytic activity. Molybdenum is bound to a unique pterin, thus forming the molybdenum cofactor (Moco), which, in different variants, is the active compound at the catalytic site of all molybdenum-containing enzymes in nature, except bacterial molybdenum nitrogenase. The biosynthesis of Moco involves the complex interaction of six proteins and is a process of four steps, which also require iron, ATP, and copper. After its synthesis, Moco is distributed, involving Moco-binding proteins. A deficiency in the biosynthesis of Moco has lethal consequences for the respective organisms.
过渡元素钼需要与特殊辅因子络合才能获得催化活性。钼与独特的蝶呤结合，从而形成钼辅因子（Moco），不同变体的 Moco 是自然界中所有含钼酶的催化部位的活性化合物，除了细菌钼氮酶。Moco 的生物合成涉及六种蛋白质的复杂相互作用，是一个四步过程，还需要铁、ATP 和铜。合成后，Moco 分布涉及 Moco 结合蛋白。Moco 生物合成的缺陷对相应的生物体有致命的后果。
