mTOR 在衰老、代谢和癌症中的作用。
mTOR in aging, metabolism, and cancer.
机构信息
Biozentrum, University of Basel, CH-4056 Basel, Switzerland.
出版信息
Curr Opin Genet Dev. 2013 Feb;23(1):53-62. doi: 10.1016/j.gde.2012.12.005. Epub 2013 Jan 11.
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase that is part of two structurally and functionally distinct complexes, TORC1 and TORC2. In multicellular organisms, TOR regulates cell growth and metabolism in response to nutrients, growth factors and cellular energy. Deregulation of TOR signaling alters whole body metabolism and causes age-related disease. This review describes the most recent advances in TOR signaling with a particular focus on mammalian TOR (mTOR) in metabolic tissues vis-a-vis aging, obesity, type 2 diabetes, and cancer.
雷帕霉素靶蛋白（TOR）是一种高度保守的丝氨酸/苏氨酸激酶，是两种结构和功能不同的复合物 TORC1 和 TORC2 的组成部分。在多细胞生物中，TOR 调节细胞生长和代谢，以响应营养物质、生长因子和细胞能量。TOR 信号的失调会改变全身代谢，并导致与年龄相关的疾病。本综述描述了 TOR 信号的最新进展，特别关注代谢组织中的哺乳动物 TOR（mTOR）与衰老、肥胖、2 型糖尿病和癌症的关系。
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