Internal Medicine Clinic, Giannitsa General Hospital, Giannitsa, Greece.
Int J Infect Dis. 2013 Jul;17(7):e494-7. doi: 10.1016/j.ijid.2012.12.006. Epub 2013 Jan 11.
To investigate the extent to which Greek patients with West Nile virus neuroinvasive disease (WNND) recovered from the initial infection in 2010, when a West Nile virus (WNV) lineage 2 outbreak took place.
Twenty-two patients with WNND were examined 16 months after the onset of symptoms. The physical and mental function of the 22 survivors was evaluated.
A considerable persistent morbidity and long length of time to recovery was observed. The most common symptoms were anorexia (77.3%) and muscle weakness (72.7%), followed by memory impairment (36.4%) and depression (22.7%). Older age was correlated with memory impairment, muscle weakness, and permanent damage. A complete recovery was seen in 7/22 (31.8%) patients, while three patients presented permanent damage. The critical time-point was 1 year after the onset of symptoms; at that time the patient's health status was either highly improved or had deteriorated irreversibly.
WNND is associated with considerable short- and long-term morbidity and mortality. Lineage 2 strains need further scientific attention. Public health measures are needed to prevent the infection, especially in the elderly with underlying diseases.
探究 2010 年希腊西尼罗河病毒神经侵袭性疾病（WNND）患者在西尼罗河病毒（WNV）2 型流行时从初始感染中恢复的程度。
对 22 例 WNND 患者在症状发作后 16 个月进行检查。评估 22 例幸存者的身体和精神功能。
观察到相当大的持续发病率和较长的恢复时间。最常见的症状是食欲不振（77.3%）和肌肉无力（72.7%），其次是记忆力减退（36.4%）和抑郁（22.7%）。年龄较大与记忆力减退、肌肉无力和永久性损害相关。22 例患者中有 7 例（31.8%）完全康复，3 例患者出现永久性损害。关键时间点是症状发作后 1 年；此时患者的健康状况要么高度改善，要么不可逆转地恶化。
WNND 与相当大的短期和长期发病率和死亡率相关。2 型谱系需要进一步的科学关注。需要采取公共卫生措施来预防感染，特别是在患有基础疾病的老年人中。
