Adam Awadalkareem, Cuellar Servando, Wang Tian
Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
School of Medicine, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Fac Rev. 2021 Jan 25;10:5. doi: 10.12703/r/10-5. eCollection 2021.
Flaviviruses are a group of mosquito- or tick-borne single-stranded RNA viruses that can cause a wide range of clinical manifestations in humans and animals, including asymptomatic, flu-like febrile illness, hemorrhagic fever, encephalitis, birth defects, and death. Many of them have no licensed vaccines available for human use. Memory B cell development and induction of neutralizing antibody responses, which are important for the control of flavivirus infection and dissemination, have been used as biomarkers for vaccine efficacy. In this review, we will discuss recent findings on memory B cells and antibody responses from studies in clinical specimen and animal models of flavivirus infection and vaccination with a focus on several clinically important flaviviruses, including dengue, West Nile, yellow fever, and Zika viruses.
黄病毒是一类由蚊子或蜱传播的单链RNA病毒，可在人类和动物中引起广泛的临床表现，包括无症状、流感样发热疾病、出血热、脑炎、出生缺陷和死亡。其中许多病毒尚无获批用于人类的疫苗。记忆B细胞的发育和中和抗体反应的诱导对控制黄病毒感染和传播很重要，已被用作疫苗效力的生物标志物。在本综述中，我们将讨论黄病毒感染和疫苗接种的临床标本及动物模型研究中关于记忆B细胞和抗体反应的最新发现，重点关注几种具有临床重要性的黄病毒，包括登革热病毒、西尼罗河病毒、黄热病毒和寨卡病毒。
