Department of Electrical and Computer Engineering, University of Calgary, Calgary, Alberta, Canada.
Gastrointest Endosc. 2013 Feb;77(2):272-9. doi: 10.1016/j.gie.2012.10.016.
Capsule endoscopy is a noninvasive method for examining the small intestine. Recently, this method has been used to visualize the colon. However, the capsule often tumbles in the wider colon lumen, resulting in potentially missed pathology. In addition, the capsule does not have the ability to distend collapsed segments of the organ. Self-stabilizing capsule endoscopy is a new method of visualizing the colon without tumbling and with the ability to passively distend colon walls.
To quantitatively compare the detection rate of intraluminal suture marker lesions for colonoscopy by using a custom-modified, self-stabilizing capsule endoscope (SCE); an unmodified capsule endoscope (CE) of the same brand; and a standard colonoscope.
Four mongrel dogs underwent laparotomy and the implantation of 5 to 8 suture markers to approximate colon lesions. Each dog had both capsule endoscopy and self-stabilizing capsule endoscopy, administered consecutively in random order. In each case, the capsule was inserted endoscopically into the proximal lumen of the colon followed by pharmacologically induced colon peristalsis to propel it distally through the colon. Blinded standard colonoscopy was performed by an experienced gastroenterologist after the capsule endoscopies.
Experimental study in a live canine model.
Four dogs.
Laparotomy, capsule endoscopy, colonoscopy.
Comparison of the marker detection rate of the SCE to that of the unmodified MiroCam CE and a colonoscope.
The average percentages of the marker detection rate for unmodified capsule endoscopy, self-stabilizing capsule endoscopy, and colonoscopy, respectively, were 31.1%, 86%, and 100% (P < .01), with both self-stabilizing capsule endoscopy and colonoscopy performing significantly better than the unmodified capsule endoscopy.
Acute canine model, suture markings poorly representative of epithelial polyps, limited number of animals.
The proposed self-stabilizing capsule endoscope delivered a significant improvement in detection rates of colon suture markings when compared with the unmodified capsule endoscope.
胶囊内镜是非侵入性的小肠检查方法。最近，该方法已用于观察结肠。然而，胶囊在更宽的结肠管腔中经常翻滚，导致潜在的病理遗漏。此外，胶囊没有使器官塌陷段膨胀的能力。自稳定胶囊内镜是一种可视化结肠而不翻滚且具有被动扩张结肠壁能力的新方法。
定量比较使用定制的自稳定胶囊内镜（SCE）、同一品牌的未修改胶囊内镜（CE）和标准结肠镜检查对结肠腔内缝线标记病变的检测率。
四只杂种狗接受了剖腹手术并植入了 5 到 8 个缝线标记物以模拟结肠病变。每只狗都进行了胶囊内镜和自稳定胶囊内镜检查，顺序随机进行。在每种情况下，将胶囊内窥镜插入近端结肠腔，然后用药理学诱导的结肠蠕动将其推进穿过结肠。胶囊内镜检查后，由经验丰富的胃肠病学家进行盲法标准结肠镜检查。
活体犬模型的实验研究。
四只狗。
剖腹手术、胶囊内镜、结肠镜检查。
比较 SCE 与未修改的 MiroCam CE 和结肠镜的标记物检测率。
未修改的胶囊内镜、自稳定胶囊内镜和结肠镜的平均标记物检测率分别为 31.1%、86%和 100%（P<.01），自稳定胶囊内镜和结肠镜的检测率均明显优于未修改的胶囊内镜。
急性犬模型、缝线标记物不能很好地代表上皮息肉、动物数量有限。
与未修改的胶囊内镜相比，所提出的自稳定胶囊内镜在检测结肠缝线标记物方面有显著提高。
