Discipline of Exercise and Sports Science, Faculty of Health Sciences, The University of Sydney, Sydney, Australia.
J Am Med Dir Assoc. 2013 Apr;14(4):236-41. doi: 10.1016/j.jamda.2012.11.012. Epub 2013 Jan 11.
Parkinson's disease (PD) is a debilitating chronic progressive neurodegenerative disorder. Currently, the treatments for PD are medications to control symptoms, however, the consequences of these motor symptoms cannot be fully eliminated and disability remains. Resistance exercise programs may be an effective strategy to delay or reverse functional decline for people with PD. The aim of this systematic review was to provide a synthesis of the evidence from controlled trials to determine whether resistance training is effective for the treatment of PD.
A comprehensive systematic database search was performed including Medline, Embase, Cinahl, SportDiscus, AMED, Pedro, and PreMedline. Studies were then assessed for potential inclusion. Study quality indicators, cohort characteristics, interventions, and muscle strength and functional performance outcomes were extracted.
Five studies were reviewed; three were randomized controlled trials (RCTs) and two were nonrandomized controlled trials. In general, the quality of the studies was moderately robust, with the three RCTs scoring 7-9, whereas the other two studies scored 4 and 6 out of 11 quality criteria. Resistance training was shown to have a positive effect in both muscle strength outcomes as well as functional outcomes related to mobility in this population. Resistance training was shown to increase fat free mass, muscle strength, and endurance as well as improve mobility and performance in functional tasks in this population.
RCTs of robust design prescribing resistance training using thorough, standardized reporting of interventions and outcomes are needed. Further research is needed to identify the ideal prescription of resistance training needed to elicit improvements in strength and functional outcomes.
帕金森病（PD）是一种使人衰弱的慢性进行性神经退行性疾病。目前，PD 的治疗方法是用药物控制症状，但这些运动症状的后果并不能完全消除，残疾仍然存在。阻力运动方案可能是延缓或逆转 PD 患者功能下降的有效策略。本系统评价的目的是综合对照试验的证据，以确定阻力训练是否对 PD 的治疗有效。
进行了全面的系统数据库搜索，包括 Medline、Embase、Cinahl、SportDiscus、AMED、 Pedro 和 PreMedline。然后评估了研究的潜在纳入情况。提取了研究质量指标、队列特征、干预措施以及肌肉力量和功能表现结果。
综述了五项研究；三项为随机对照试验（RCT），两项为非随机对照试验。总体而言，研究的质量相当可靠，三项 RCT 的评分为 7-9，而另外两项研究的评分为 4 和 6 分（共 11 分）。阻力训练在该人群的肌肉力量和与移动性相关的功能结果方面均显示出积极的效果。阻力训练被证明可以增加去脂体重、肌肉力量和耐力，以及改善该人群的移动性和功能任务表现。
需要使用彻底、标准化的干预措施和结果报告来制定阻力训练的 RCT。需要进一步研究以确定引起力量和功能结果改善的阻力训练的理想方案。
