达托霉素与万古霉素治疗实验性兔耐甲氧西林金黄色葡萄球菌性脑膜炎的比较。
Daptomycin versus vancomycin in treatment of methicillin-resistant Staphylococcus aureus meningitis in an experimental rabbit model.
机构信息
Ege University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey.
出版信息
Antimicrob Agents Chemother. 2013 Mar;57(3):1556-8. doi: 10.1128/AAC.01996-12. Epub 2013 Jan 14.
Abstract
In this study, we aimed to compare the antibacterial activities of daptomycin and vancomycin in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) meningitis (induced by MRSA strain ATCC 43300) in an experimental rabbit meningitis model. After an 8-h period of treatment, bacterial counts decreased significantly in both treatment groups compared to the control group (P < 0.05). However, there was no statistically significant difference between treatment groups. Our results suggest that the antibacterial activity of daptomycin is similar to vancomycin for treatment in the experimental MRSA meningitis model in rabbits.
摘要
在这项研究中，我们旨在比较达托霉素和万古霉素在实验性兔脑膜炎模型中治疗耐甲氧西林金黄色葡萄球菌（MRSA）脑膜炎（由 MRSA 株 ATCC 43300 诱导）中的抗菌活性。经过 8 小时的治疗后，与对照组相比，两组治疗组的细菌计数均明显下降（P<0.05）。然而，两组之间没有统计学上的显著差异。我们的结果表明，达托霉素的抗菌活性与万古霉素在治疗实验性兔耐甲氧西林金黄色葡萄球菌脑膜炎模型中相似。
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