在实验性脑膜炎中，达托霉素对甲氧西林敏感金黄色葡萄球菌的疗效优于万古霉素。
Daptomycin is more efficacious than vancomycin against a methicillin-susceptible Staphylococcus aureus in experimental meningitis.
作者信息
Gerber Peter, Stucki Armin, Acosta Fernando, Cottagnoud Marianne, Cottagnoud Philippe
机构信息
Clinic of Pneumology, Inselspital, Bern, Switzerland.
出版信息
J Antimicrob Chemother. 2006 Apr;57(4):720-3. doi: 10.1093/jac/dkl007. Epub 2006 Feb 3.
OBJECTIVES
To test the efficacy of daptomycin, a cyclic lipopeptide antibiotic, against a methicillin-susceptible Staphylococcus aureus strain in experimental rabbit meningitis and to determine its penetration into non-inflamed and inflamed meninges
RESULTS
Over a treatment period of 8 h, daptomycin (15 mg/kg) was significantly superior to the comparator regimen vancomycin (-4.54 +/- 1.12 log(10)/mL for daptomycin versus -3.43 +/- 1.17 log(10)/mL for vancomycin). Daptomycin managed to sterilize 6 out of 10 CSFs compared with 4 out of 10 for vancomycin. The penetration of daptomycin into inflamed meninges was approximately 5% and approximately 2% into non-inflamed meninges.
CONCLUSIONS
The superior bactericidal activity of daptomycin was confirmed in vivo and in time-killing assays in vitro.
目的
在实验性兔脑膜炎模型中测试环脂肽抗生素达托霉素对甲氧西林敏感金黄色葡萄球菌菌株的疗效，并确定其在非炎症性和炎症性脑膜中的渗透情况。
结果
在8小时的治疗期内，达托霉素（15mg/kg）显著优于对照方案万古霉素（达托霉素为-4.54±1.12 log₁₀/mL，万古霉素为-3.43±1.17 log₁₀/mL）。达托霉素使10份脑脊液中的6份除菌，而万古霉素为10份中的4份。达托霉素在炎症性脑膜中的渗透率约为5%，在非炎症性脑膜中的渗透率约为2%。
结论
达托霉素在体内和体外时间杀菌试验中均证实具有卓越的杀菌活性。
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