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本文引用的文献

1
Epidemiology and molecular mechanism of integron-mediated antibiotic resistance in Shigella.志贺菌中整合子介导的抗生素耐药性的流行病学和分子机制。
Arch Microbiol. 2011 Nov;193(11):767-74. doi: 10.1007/s00203-011-0744-3. Epub 2011 Aug 14.
2
Superbug demands organizational change of the healthcare system.超级细菌要求医疗保健系统进行组织变革。
J Pharmacol Pharmacother. 2011 Apr;2(2):132-3. doi: 10.4103/0976-500X.81915.
3
Decreased susceptibility to ciprofloxacin among Shigella isolates in the United States, 2006 to 2009.2006 至 2009 年美国志贺氏菌分离株对环丙沙星的敏感性降低。
Antimicrob Agents Chemother. 2011 Apr;55(4):1758-60. doi: 10.1128/AAC.01463-10. Epub 2011 Jan 10.
4
NDM-1--a cause for worldwide concern.新德里金属-β-内酰胺酶-1——一个引起全球关注的因素。
N Engl J Med. 2010 Dec 16;363(25):2377-9. doi: 10.1056/NEJMp1011715.
5
Prevalence and characterization of human Shigella infections in Henan Province, China, in 2006.2006 年中国河南省人类志贺氏菌感染的流行情况及特征。
J Clin Microbiol. 2011 Jan;49(1):232-42. doi: 10.1128/JCM.01508-10. Epub 2010 Nov 10.
6
Origins and evolution of antibiotic resistance.抗生素耐药性的起源与演变。
Microbiol Mol Biol Rev. 2010 Sep;74(3):417-33. doi: 10.1128/MMBR.00016-10.
7
Emergence of a new multidrug-resistant serotype X variant in an epidemic clone of Shigella flexneri.福氏志贺菌流行克隆中新出现的一种耐药性血清型 X 变种。
J Clin Microbiol. 2010 Feb;48(2):419-26. doi: 10.1128/JCM.00614-09. Epub 2009 Dec 2.
8
Surveillance of antibiotic susceptibility patterns among Shigella sonnei strains isolated in Belgium during the 18-year period 1990 to 2007.1990年至2007年18年间比利时分离出的宋内志贺菌菌株抗生素敏感性模式监测。
J Clin Microbiol. 2009 May;47(5):1379-85. doi: 10.1128/JCM.02460-08. Epub 2009 Mar 25.
9
Integron-mediated multidrug resistance in a global collection of nontyphoidal Salmonella enterica isolates.整合子介导的全球非伤寒型肠炎沙门氏菌分离株集合中的多药耐药性。
Emerg Infect Dis. 2009 Mar;15(3):388-96. doi: 10.3201/eid1503.081131.
10
Conjugation potential and class 1 integron carriage of resident plasmids in river water copiotrophs.河水富养菌中常驻质粒的接合潜力与1类整合子携带情况
Acta Microbiol Immunol Hung. 2007 Dec;54(4):379-97. doi: 10.1556/AMicr.54.2007.4.5.

中国东部地区志贺菌分离株的抗生素耐药性和整合子分子特征。

High prevalence of antibiotic resistance and molecular characterization of integrons among Shigella isolates in Eastern China.

机构信息

Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.

出版信息

Antimicrob Agents Chemother. 2013 Mar;57(3):1549-51. doi: 10.1128/AAC.02102-12. Epub 2013 Jan 14.

DOI:10.1128/AAC.02102-12
PMID:23318797
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3591917/
Abstract

A total of 747 Shigella isolates were collected from hospitals in Jiangsu Province of China. Susceptibilities to antimicrobials and integrons were tested. A total of 78.3% of S. flexneri isolates and a total of 74.3% S. sonei isolates were resistant to at least three antibiotics. Of the Shigella isolates, 74.7% had integron I and 82.6% had integron II. The conjunction of the high prevalence of integrons in Shigella and high resistance to antimicrobials will lead to rapid dissemination of resistant genes in this region.

摘要

共从中国江苏省的医院收集了 747 株志贺氏菌分离株。对其进行了药敏试验和整合子检测。78.3%的福氏志贺菌分离株和 74.3%的宋内志贺菌分离株至少对三种抗生素耐药。在志贺氏菌分离株中，74.7%有整合子 I，82.6%有整合子 II。志贺氏菌中整合子的高流行率和对抗生素的高度耐药性将导致该地区耐药基因的快速传播。