哈利·李·帕克与发作性构音障碍和共济失调。
Harry Lee Parker and paroxysmal dysarthria and ataxia.
机构信息
Mayo Clinic, Rochester, MN, USA.
出版信息
Neurology. 2013 Jan 15;80(3):311-4. doi: 10.1212/WNL.0b013e31827dec0f.
OBJECTIVE
To review descriptions of paroxysmal dysarthria and ataxia in multiple sclerosis (MS), with special attention given to Parker and his 1946 case series.
METHODS
Evaluation of original publications describing paroxysmal dysarthria and ataxia, bibliographic information, writings, and unpublished letters from the Mayo Clinic Historical Unit.
RESULTS
In 1940, Störring described a patient with MS with paroxysmal symptoms that included dizziness and trouble speaking, but also unilateral extremity weakness. In 1946, Parker published a series of 11 patients with paroxysmal dysarthria and ataxia. Six of these patients had MS, and he recognized this phenomenon as a manifestation of the disease. The term "paroxysmal dysarthria and ataxia" was first used in 1959 by Andermann and colleagues. Since that time, paroxysmal dysarthria and ataxia has become a well-recognized phenomenon in MS. More recent reports have suggested that the responsible lesion is located in the midbrain, near or involving the red nucleus.
CONCLUSIONS
Parker was the first to accurately describe paroxysmal dysarthria and ataxia in patients with MS.
目的
回顾多发性硬化症（MS）中发作性构音障碍和共济失调的描述，特别关注 Parker 及其 1946 年的病例系列。
方法
评估描述发作性构音障碍和共济失调的原始出版物、书目信息、著作以及梅奥诊所历史部门的未发表信件。
结果
1940 年，Störring 描述了一例 MS 患者，其阵发性症状包括头晕和言语障碍，但也有单侧肢体无力。1946 年，Parker 发表了一系列 11 例发作性构音障碍和共济失调患者。其中 6 例患有 MS，他将这种现象视为疾病的一种表现。“发作性构音障碍和共济失调”一词最早于 1959 年由 Andermann 等人使用。自那时以来，发作性构音障碍和共济失调已成为 MS 中一种公认的现象。最近的报告表明，责任病变位于中脑，靠近或涉及红核。
结论
Parker 是第一个准确描述 MS 患者发作性构音障碍和共济失调的人。
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