突变型和野生型 Ras：癌症的共犯。
Mutant and wild-type Ras: co-conspirators in cancer.
机构信息
Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
出版信息
Cancer Discov. 2013 Jan;3(1):24-6. doi: 10.1158/2159-8290.CD-12-0521.
Abstract
Although the functional interplay between mutant and wild-type Ras in driving tumor initiation and growth has been described, a clear picture of the precise ramifications and mechanisms of this association remains elusive, sometimes with conflicting conclusions. A report in this issue of Cancer Discovery tackles this question, which may have important implications for therapeutic strategies to block mutant Ras for cancer treatment.
摘要
虽然已经描述了突变型和野生型 Ras 之间的功能相互作用在驱动肿瘤起始和生长中的作用，但这种关联的确切后果和机制仍不明确，有时甚至得出相互矛盾的结论。本期《癌症发现》杂志上的一篇报道解决了这个问题，这对于阻止突变型 Ras 用于癌症治疗的治疗策略可能具有重要意义。
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Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis.Sos 通过癌基因 Ras 介导的野生型 Ras 交叉激活对于肿瘤发生是必不可少的。
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