Division of Medical Oncology, Section of Breast Oncology, Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cancer Discov. 2013 Jan;3(1):27-34. doi: 10.1158/2159-8290.CD-12-0462.
The application of high-throughput techniques to profile DNA, RNA, and protein in breast cancer samples from hundreds of patients has profoundly increased our knowledge of the disease. The etiologic events that drive breast cancer are finally coming into focus and should be used to set priorities for clinical trials. In this Prospective, we summarize some of the headline conclusions from 6 recent breast cancer "omics profiling" articles in Nature, with an emphasis on the implications for systemic therapy.
高通量技术在数百例乳腺癌样本的 DNA、RNA 和蛋白质分析中的应用，极大地提高了我们对这种疾病的认识。推动乳腺癌发生的病因事件终于逐渐明朗，这些发现应该被用于指导临床试验的重点方向。在本篇前瞻性综述中，我们总结了 Nature 杂志上最近 6 篇乳腺癌“组学分析”文章的一些重要结论，重点强调了这些发现对系统治疗的意义。
