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钆（3+）掺杂介孔硅纳米粒子作为一种潜在的磁共振示踪剂用于监测体内干细胞的迁移。

Gadolinium(3+)-doped mesoporous silica nanoparticles as a potential magnetic resonance tracer for monitoring the migration of stem cells in vivo.

机构信息

Imaging Diagnostic and Interventional Center, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.

出版信息

Int J Nanomedicine. 2013;8:119-27. doi: 10.2147/IJN.S38213. Epub 2013 Jan 4.

DOI:10.2147/IJN.S38213
PMID:23319863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3540969/
Abstract

We investigated the tracking potential of a magnetic resonance imaging (MRI) probe made of gadolinium-doped mesoporous silica MCM-41 (Gd(2)O(3)@MCM-41) nanoparticles for transplanted bone mesenchymal stem cells (MSCs) and neural stem cells (NSCs) in vivo. The nanoparticles, synthesized using a one-step synthetic method, possess hexagonal mesoporous structures with appropriate assembly of nanoscale Gd(2)O(3) clusters. They show little cytotoxicity against proliferation and have a lower effect on the inherent differentiation potential of these labeled stem cells. The tracking of labeled NSCs in murine brains was dynamically determined with a clinical 3T MRI system for at least 14 days. The migration of labeled NSCs identified by MRI corresponded to the results of immunofluorescence imaging. Our study confirms that Gd(2)O(3)@MCM-41 particles can serve as an ideal vector for long-term MRI tracking of MSCs and NSCs in vivo.

摘要

我们研究了由掺杂钆的介孔硅 MCM-41（Gd2O3@MCM-41）纳米粒子制成的磁共振成像（MRI）探针在体内对移植的骨髓间充质干细胞（MSCs）和神经干细胞（NSCs）的跟踪潜力。这些纳米粒子使用一步合成法合成，具有适当组装的纳米级 Gd2O3 簇的六方介孔结构。它们对增殖的细胞毒性很小，对这些标记的干细胞的固有分化潜能的影响也较小。使用临床 3T MRI 系统至少 14 天来动态确定标记的 NSCs 在小鼠脑中的迁移情况。MRI 鉴定的标记 NSCs 的迁移与免疫荧光成像的结果一致。我们的研究证实，Gd2O3@MCM-41 颗粒可用作体内 MSC 和 NSCs 长期 MRI 跟踪的理想载体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/a868e17b97fd/ijn-8-119f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/86ed9738dc48/ijn-8-119f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/89b48354004f/ijn-8-119f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/cc62022a8f7c/ijn-8-119f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/6052a53f88a4/ijn-8-119f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/a868e17b97fd/ijn-8-119f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/86ed9738dc48/ijn-8-119f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/89b48354004f/ijn-8-119f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/cc62022a8f7c/ijn-8-119f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/6052a53f88a4/ijn-8-119f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fed/3540969/a868e17b97fd/ijn-8-119f5.jpg

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