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一例人疱疹病毒8型相关性原发性渗出性淋巴瘤样淋巴瘤以胸腔积液形式呈现。

A case of human herpes virus-8 unrelated primary effusion lymphoma-like lymphoma presented as pleural effusion.

作者信息

Kim Kyung Ho, Lee Ji-Hyun, Jeong Hye Cheol, Kim Gun-Woo, Song Sang Hee, Jung So-Young, Kim Gwang Il, Kim Eun Kyung

机构信息

Department of Internal Medicine, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, Korea.

出版信息

Tuberc Respir Dis (Seoul). 2012 Dec;73(6):336-41. doi: 10.4046/trd.2012.73.6.336. Epub 2012 Dec 28.

DOI:10.4046/trd.2012.73.6.336
PMID:23319997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3538188/
Abstract

Primary effusion lymphoma (PEL) is a rare type of lymphoma that arises in the body cavity without detectable masses. It is associated with human herpes virus-8 (HHV-8), Epstein-Barr virus (EBV), and human immunodeficiency virus (HIV). Recently, PEL unrelated to viral infection has been reported and it has been termed HHV-8 unrelated primary effusion lymphoma-like lymphoma (HHV-8 unrelated PEL-like lymphoma). Here, we report a case of HHV-8 unrelated PEL-like lymphoma in an 80-year-old woman. Chest X-ray and computed tomography revealed left-sided pleural effusion. Pleural effusion analysis and mediastinoscopic biopsy showed atypical cells that had originated from the B cells. The cells were positive for CD20 and bcl-2, but negative for CD3, CD5, CD21, CD30, CD138, epithelial membrane antigen, and HHV-8. Serological tests for HIV and EBV were negative. Considering the patient's age, further treatments were not performed. She has shown good prognosis without chemotherapy for more than 18 months.

摘要

原发性渗出性淋巴瘤（PEL）是一种罕见的淋巴瘤类型，发生于体腔且无可检测到的肿块。它与人类疱疹病毒8型（HHV-8）、爱泼斯坦-巴尔病毒（EBV）和人类免疫缺陷病毒（HIV）有关。最近，有报道称存在与病毒感染无关的PEL，它被称为HHV-8无关的原发性渗出性淋巴瘤样淋巴瘤（HHV-8无关的PEL样淋巴瘤）。在此，我们报告一例80岁女性的HHV-8无关的PEL样淋巴瘤病例。胸部X线和计算机断层扫描显示左侧胸腔积液。胸腔积液分析和纵隔镜活检显示有起源于B细胞的非典型细胞。这些细胞CD20和bcl-2呈阳性，但CD3、CD5、CD21、CD30、CD138、上皮膜抗原和HHV-8呈阴性。HIV和EBV的血清学检测均为阴性。考虑到患者年龄，未进行进一步治疗。她在未接受化疗的情况下已显示出超过18个月的良好预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d8/3538188/f48176177c53/trd-73-336-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d8/3538188/e4e928ec89dd/trd-73-336-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d8/3538188/5f0c58b8e495/trd-73-336-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d8/3538188/9c5422b3ca86/trd-73-336-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d8/3538188/f48176177c53/trd-73-336-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d8/3538188/e4e928ec89dd/trd-73-336-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d8/3538188/5f0c58b8e495/trd-73-336-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d8/3538188/9c5422b3ca86/trd-73-336-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42d8/3538188/f48176177c53/trd-73-336-g004.jpg

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