Kim Moonsik, An Jiyeon, Yoon Sun Och, Yong Seung Hyun, Kim Jin Seok, Yang Woo Ick, Leem Ah Young
Department of Pathology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Division of Pulmonology, Department of Internal Medicine, Institute of Chest Diseases, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Oncol Lett. 2020 Dec;20(6):343. doi: 10.3892/ol.2020.12206. Epub 2020 Oct 8.
Primary effusion lymphoma (PEL) is a B-cell non-Hodgkin's lymphoma that is usually characterized by lymphomatous effusions in the body cavity without any detectable tumor masses. According to the World Health Organization (WHO) schema for tumor classification, PEL is defined by the presence of human herpesvirus 8 (HHV8) in malignant lymphoid cells. However, a subset of effusion-based B-cell lymphoma is not HHV8-positive and exhibits different clinicopathological characteristics. The 2017 WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues does not list HHV8-negative effusion-based lymphoma, which remains an underappreciated B-cell lymphoma, as an individual entity. The present study reports a case of this rare type of lymphoma with indolent clinical behavior in a 75-year-old male patient receiving only symptomatic treatment. Additionally, a review of similar cases reported in the English literature is presented.
原发性渗出性淋巴瘤（PEL）是一种B细胞非霍奇金淋巴瘤，其通常特征为体腔内出现淋巴瘤性渗出液，而无任何可检测到的肿瘤肿块。根据世界卫生组织（WHO）肿瘤分类方案，PEL由恶性淋巴样细胞中存在人类疱疹病毒8（HHV8）来定义。然而，一部分基于渗出液的B细胞淋巴瘤并非HHV8阳性，且表现出不同的临床病理特征。《2017年WHO造血与淋巴组织肿瘤分类》未将HHV8阴性的基于渗出液的淋巴瘤列为一个独立实体，这种淋巴瘤仍然是一种未得到充分认识的B细胞淋巴瘤。本研究报告了一例75岁男性患者发生的这种罕见类型淋巴瘤，其临床行为惰性，仅接受了对症治疗。此外，还对英文文献中报道的类似病例进行了综述。
