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苦瓜甲醇提取物对人肺腺癌细胞 CL1 的抗迁移作用。

Antimigratory Effects of the Methanol Extract from Momordica charantia on Human Lung Adenocarcinoma CL1 Cells.

机构信息

Department of Life Sciences, Tzu-Chi University, Hualien, Taiwan ; Institute of Medical Sciences, Tzu-Chi University, Hualien, Taiwan.

出版信息

Evid Based Complement Alternat Med. 2012;2012:819632. doi: 10.1155/2012/819632. Epub 2012 Dec 18.

DOI:10.1155/2012/819632
PMID:23320038
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3535856/
Abstract

Momordica charantia has been found to exhibit anticancer activity, in addition to its well-known therapeutic functions. We have demonstrated that the leaf extract of Momordica charantia (MCME) induces apoptosis in several human cancer cells through caspase- and mitochondria-dependent pathways. In this study, a different susceptibility to MCME was found in human lung adenocarcinoma CL1 cells with different metastatic ability, leading to the significant difference of cell viability and invasiveness between MCME-treated CL1-0 and CL1-5 cells. MCME was found to upregulate the expression of Wnt-2 and affect the migratory and invasive ability of CL1 cells through suppressed MMP-2 and MMP-9 enzymatic activities. We proposed that MCME mediates inhibition against migration of CL1 cells by reducing the expression and activation of Src and FAK to decrease the expression of downstream Akt, β-catenin, and MMPs.

摘要

苦瓜除了众所周知的治疗功能外，还被发现具有抗癌活性。我们已经证明苦瓜叶提取物（MCME）通过半胱天冬酶和线粒体依赖性途径诱导几种人类癌细胞凋亡。在这项研究中，具有不同转移能力的人肺腺癌细胞 CL1 对 MCME 的敏感性不同，导致 MCME 处理的 CL1-0 和 CL1-5 细胞之间的细胞活力和侵袭性存在显著差异。MCME 被发现上调 Wnt-2 的表达，并通过抑制 MMP-2 和 MMP-9 的酶活性来影响 CL1 细胞的迁移和侵袭能力。我们提出 MCME 通过减少 Src 和 FAK 的表达和激活来降低下游 Akt、β-连环蛋白和 MMPs 的表达，从而介导对 CL1 细胞迁移的抑制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ee/3535856/914526459546/ECAM2012-819632.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ee/3535856/914526459546/ECAM2012-819632.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83ee/3535856/914526459546/ECAM2012-819632.006.jpg

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