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瓜蒌苦素，一种从苦瓜藤中分离得到的环烯醚萜类化合物的抗菌和抗增殖活性。

Antibacterial and Antiproliferative Activities of Plumericin, an Iridoid Isolated from Momordica charantia Vine.

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayudhya Road, Rajthevi, Bangkok 10400, Thailand.

Department of Biotechnology, Faculty of Applied Science, King Mongkut's University of Technology North Bangkok, Bangsue, Bangkok 10800, Thailand.

出版信息

Evid Based Complement Alternat Med. 2015;2015:823178. doi: 10.1155/2015/823178. Epub 2015 Apr 7.

DOI:10.1155/2015/823178
PMID:25945113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4405293/
Abstract

Plumericin, an iridoid lactone, was isolated with relatively high yield from Momordica charantia vine using the supercritical fluid extraction (SFE) and the separation box (Sepbox) comprising dual combination of high-performance liquid chromatography and solid phase extraction. This compound showed antibacterial activity against Enterococcus faecalis and Bacillus subtilis with minimum inhibitory concentration (MIC) values better than cloxacillin. Plumericin potently inhibited proliferation of two leukemic cancer cell lines: they were acute and chronic leukemic cancer cell lines, NB4 and K562, with the effective doses (ED50) of 4.35 ± 0.21 and 5.58 ± 0.35 μg/mL, respectively. In addition, the mechanism of growth inhibition in both cell lines was induced by apoptosis, together with G2/M arrest in K562 cells.

摘要

瓜馥木宁，一种裂环环烯醚萜内酯，采用超临界流体萃取（SFE）和包含高效液相色谱和固相萃取双重组合的分离箱（Sepbox），从苦瓜藤中以较高产率分离得到。该化合物对粪肠球菌和枯草芽孢杆菌表现出抗菌活性，最低抑菌浓度（MIC）值优于氯唑西林。瓜馥木宁强烈抑制两种白血病癌细胞系的增殖：它们是急性和慢性白血病癌细胞系 NB4 和 K562，有效剂量（ED50）分别为 4.35±0.21 和 5.58±0.35μg/mL。此外，两种细胞系的生长抑制机制均诱导细胞凋亡，并导致 K562 细胞 G2/M 期阻滞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/52a6c1787c44/ECAM2015-823178.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/cc9aacf11c15/ECAM2015-823178.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/382feeae9a58/ECAM2015-823178.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/185c0720c71a/ECAM2015-823178.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/ee78ca4189b1/ECAM2015-823178.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/2b3487b0a3bf/ECAM2015-823178.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/52a6c1787c44/ECAM2015-823178.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/cc9aacf11c15/ECAM2015-823178.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/382feeae9a58/ECAM2015-823178.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/185c0720c71a/ECAM2015-823178.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/ee78ca4189b1/ECAM2015-823178.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/2b3487b0a3bf/ECAM2015-823178.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a7/4405293/52a6c1787c44/ECAM2015-823178.006.jpg

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2
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Br J Pharmacol. 2014 Apr;171(7):1676-86. doi: 10.1111/bph.12558.
3
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4
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ACS Omega. 2023 Feb 8;8(7):6476-6491. doi: 10.1021/acsomega.2c06803. eCollection 2023 Feb 21.
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