哮喘儿童和正常儿童运动时的生长激素反应

Growth hormone response to exercise in asthmatic and normal children.

作者信息

Amirav I, Dowdeswell R J, Plit M, Panz V R, Joffe B I, Seftel H C

机构信息

Department of Medicine, J. G. Strijdom Hospital, University of the Witwatersrand, Johannesburg, South Africa.

出版信息

Eur J Pediatr. 1990 Mar;149(6):443-6. doi: 10.1007/BF02009670.

DOI:10.1007/BF02009670

PMID:2332018

Abstract

Maximal growth hormone (GH) increments following exercise were compared in asthmatic (n = 14) and normal (n = 8) children. Exercise, which consisted of 6 min ergometer cycling while breathing cold dry (CD) air, induced asthma in all asthmatic patients but not in normal subjects. Baseline plasma GH levels were similar in both groups. Following exercise, however, asthmatic patients had significantly higher mean GH increments than normal subjects (14.8 vs 4.9 ng/ml, P less than 0.025). To evaluate the possible role of bronchoconstriction in the GH response all subjects exercised again, this time while breathing warm humid (WH) air. Despite the absence of exercise-induced asthma (EIA) while breathing WH air, asthmatic patients still had significantly higher mean GH increments than normal subjects (9.2 vs 2.3 ng/ml, P less than 0.05). We conclude that some asthmatic children show excessive GH secretion after exercise regardless of inspired air conditions or the development of EIA.

摘要

对哮喘儿童（n = 14）和正常儿童（n = 8）运动后生长激素（GH）的最大增幅进行了比较。运动内容为在呼吸冷干（CD）空气的同时进行6分钟的测力计骑行，结果所有哮喘患者均诱发了哮喘，而正常受试者未出现哮喘。两组的基线血浆GH水平相似。然而，运动后哮喘患者的平均GH增幅显著高于正常受试者（14.8对4.9 ng/ml，P<0.025）。为评估支气管收缩在GH反应中的可能作用，所有受试者再次进行运动，此次呼吸的是温暖潮湿（WH）空气。尽管呼吸WH空气时未出现运动诱发哮喘（EIA），但哮喘患者的平均GH增幅仍显著高于正常受试者（9.2对2.3 ng/ml，P<0.05）。我们得出结论，一些哮喘儿童运动后无论吸入空气条件如何或是否发生EIA，均表现出GH分泌过多。