Amirav I, Panz V, Joffe B I, Dowdswell R, Plit M, Seftel H C
Children's Hospital of Philadelphia, PA.
Pediatr Pulmonol. 1994 Aug;18(2):99-103. doi: 10.1002/ppul.1950180208.
The influence of different inspired air conditions on exercise-induced bronchoconstriction (EIB) is well appreciated. However, the mechanism by which this influence is exerted is uncertain. To determine if varied inspired air conditions during exercise could affect the catecholamine response to physical exercise, we had 13 asthmatic and 6 healthy children (aged 10-18 years) undergo two bouts of cycle ergometry tests under different air conditions. One test was done while breathing cold dry (CD) air (temperature, -20.2 degrees C; relative humidity, 0%) and the other while breathing warm humid (WH) air (temperature, 34.3 degrees C; relative humidity, 100%). Forced expiratory volume in 1 second (FEV1) and plasma catecholamine concentrations were recorded before and after exercise. Marked EIB (48 +/- 5% SEM fall in FEV1 from baseline) developed in all asthmatics after the CD exercise, but no EIB was noted after the WH exercise. Normal controls had no EIB under either test conditions. Plasma levels of catecholamines at rest, and the changes that occurred during and after exercise, were comparable within as well as between the groups in both tests. Catecholamines did not rise in asthmatics following development of EIB. These data demonstrate that inspired air conditions do not influence the sympathoadrenal response to exercise, at least as reflected in plasma catecholamine levels. In fact, this response did not differ between asthmatics and normals, irrespective of the development of EIB. These results are consistent with previous reports about impaired catecholamine response of asthmatics to bronchoconstriction.
不同吸入空气条件对运动诱发支气管收缩（EIB）的影响已得到充分认识。然而，这种影响产生的机制尚不确定。为了确定运动期间不同的吸入空气条件是否会影响儿茶酚胺对体育锻炼的反应，我们让13名哮喘儿童和6名健康儿童（年龄10 - 18岁）在不同空气条件下进行两轮自行车测力计测试。一轮测试在呼吸冷干（CD）空气（温度，-20.2℃；相对湿度，0%）时进行，另一轮在呼吸温暖潮湿（WH）空气（温度，34.3℃；相对湿度，100%）时进行。记录运动前后的1秒用力呼气量（FEV1）和血浆儿茶酚胺浓度。所有哮喘儿童在CD运动后均出现明显的EIB（FEV1较基线下降48±5% SEM），但在WH运动后未观察到EIB。正常对照组在两种测试条件下均未出现EIB。在两次测试中，两组内以及组间静息时的血浆儿茶酚胺水平以及运动期间和运动后发生的变化均具有可比性。哮喘患者出现EIB后儿茶酚胺并未升高。这些数据表明，吸入空气条件不会影响对运动的交感肾上腺反应，至少从血浆儿茶酚胺水平来看是这样。事实上，无论EIB是否发生，哮喘患者和正常人之间的这种反应并无差异。这些结果与先前关于哮喘患者对支气管收缩的儿茶酚胺反应受损的报道一致。
