[紫藤三萜类化合物的研究]

[Study on triterpenoids from Wisteria sinensis].

作者信息

Liu Jin-Song, Chen Ai-Min, Xu Ying-Sheng, Zhang Cong-Er, Wang Gang

机构信息

School of Materia Madica, Anhui University of Traditional Chinese Medicine, Anhui Key Laboratory of Modernized Chinese Material Medical, Hefei 230031, China.

出版信息

Zhong Yao Cai. 2012 Aug;35(8):1246-50.

PMID:23320355

Abstract

OBJECTIVE

To study the triterpenoids constituents from Wisteria sinensis Sweet Caulis.

METHODS

The compounds were beta-solated and purified with silica gel and Sephadex LH-20 column chromatography from the petroleum ether extract. Their structures were determined on the basis of physicochemical properties and spectroscopic analysis.

RESULTS

They were identified as beta-sitosterol palmitate (1), alpha-spinasterol (2), (22E, 24R)-5alpha, 8alpha-epidioxy-ergosta-6, 22-dien-3beta-ol (3), (22E, 24R)-ergosta-5, 7, 22-trien-3beta-ol (4), (22E, 24R) -ergosta-7, 22-dien-3beta-ol (5), 11alpha, 12alpha-oxidotaraxerol (6), lupeol (7), betulinic acid (8), 22-oxo-3beta, 24-dihydroxyolean-12-ene (9), 2alpha, 3beta, 23-trihydroxyolean-12-ene (10), soyasapogenol E (11), 3alpha, 21beta-dihydroxy-olean-12-ene (12).

CONCLUSION

Compounds 1 - 12 are isolated from this plant for the first time.

摘要

目的

研究紫藤茎中的三萜类成分。

方法

采用硅胶柱色谱和葡聚糖凝胶LH - 20柱色谱从石油醚提取物中分离纯化化合物，根据其理化性质和光谱分析确定结构。

结果

鉴定出它们为β - 谷甾醇棕榈酸酯（1）、α - 菠菜甾醇（2）、（22E，24R）-5α，8α - 环氧麦角甾 - 6，22 - 二烯 - 3β - 醇（3）、（22E，24R）-麦角甾 - 5，7，22 - 三烯 - 3β - 醇（4）、（22E，24R）-麦角甾 - 7，22 - 二烯 - 3β - 醇（5）、11α，12α - 氧化蒲公英赛醇（6）、羽扇豆醇（7）、桦木酸（8）、22 - 氧代 - 3β，24 - 二羟基齐墩果 - 12 - 烯（9）、2α，3β，23 - 三羟基齐墩果 - 12 - 烯（10）、大豆皂醇E（11）、3α，21β - 二羟基齐墩果 - 12 - 烯（12）。