朝天罐根中的化学成分。

Chemical constituents in roots of Osbeckia opipara.

作者信息

Wang Hongsheng, Wang Yuehu, Shi Yana, Li Xingyu, Long Chunlin

机构信息

Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2009 Feb;34(4):414-8.

PMID:19459302

Abstract

OBJECTIVE

To study the chemical constituents of the roots of Osbeckia opipara.

METHOD

Repeated column chromatography over silica gel, RP-18 and Sephadex LH-20, and preparative thin layer chromatography(PTLC) were used to isolate the compounds, whose structures were determined by spectroscopic methods by direct comparing spectral data with those reported references.

RESULT

From the MeOH extract of the roots O. opipara, twelve compounds were isolated and identified as follows: lasiodiplodin (1) , de-O-methyllasiodiplodin (2), 2, 3- dihydro-2-hydroxy-2, 4-dimethyl-5-trans-propenylfuran-3-one (3), integracin (4), 5alpha, 8alpha-epidioxy-(22E, 24R)-ergosta-6, 22-dien-3beta-ol (5), 3, 3', 4'-tri-O-methylellagic acid (6), 5-hydroxymethyl furaldehyde (7), vomifolio (8) , betulintic acid (9), 2alpha-hydroxyursolic acid (10), (24R)-stigmast-4-ene-3-one (11), and eugenitin (12).

CONCLUSION

Compounds 1-12 were isolated from O. opipara for the first time.

摘要

目的

研究朝天罐根的化学成分。

方法

采用硅胶柱色谱、RP - 18柱色谱、葡聚糖凝胶LH - 20柱色谱及制备薄层色谱法分离化合物，通过将光谱数据与已报道参考文献直接比较，采用光谱方法确定化合物结构。

结果

从朝天罐根的甲醇提取物中分离鉴定出12个化合物，分别为：绵毛马兜铃酸（1）、去 - O - 甲基绵毛马兜铃酸（2）、2,3 - 二氢 - 2 - 羟基 - 2,4 - 二甲基 - 5 - 反式 - 丙烯基呋喃 - 3 - 酮（3）、整合素（4）、5α,8α - 环氧 - (22E,24R) - 麦角甾 - 6,22 - 二烯 - 3β - 醇（5）、3,3',4' - 三 - O - 甲基鞣花酸（6）、5 - 羟甲基糠醛（7）、伏地筋骨草素（8）、桦木酸（9）、2α - 羟基熊果酸（10）、(24R) - 豆甾 - 4 - 烯 - 3 - 酮（11）和番樱桃素（12）。