[鹰不泊叶挥发油的化学成分、抗菌及抗肿瘤活性研究]
[Study on the chemical components, antimicrobial and antitumor activities of the essential oil from the leaves of Zanthoxylum avicennae].
作者信息
Zhang Da-Shuai, Zhong Qiong-Xin, Song Xin-Ming, Liu Wen-Jie, Wang Jing, Zhang Qiong-Yu
机构信息
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Haikou 571158, China.
出版信息
Zhong Yao Cai. 2012 Aug;35(8):1263-7.
OBJECTIVE
To study the chemical constituents, antimicrobial activity and antitumor activity of the essential oil from Zanthoxylum avicennae.
METHODS
The essential oil from the leaves of Zanthoxylum avicennae was extracted by steam distillation. The components of the essential oil were separated and identified by GC-MS.
RESULTS
72 components were identified and accounted for 98.15% of the all peak area. The essential oil exhibited strong antitumor activity against K-562 human tumor cell lines with IC50 of 1.76 microg/mL. It also exhibited moderate antimicrobial activity against three bacteria.
CONCLUSION
The essential oil of Zanthoxylum avicennae contains various active constituents. This result provides scientific reference for the pharmacological further research of Zanthoxylum avicennae.
目的
研究鹰不泊挥发油的化学成分、抗菌活性及抗肿瘤活性。
方法
采用水蒸气蒸馏法提取鹰不泊叶中的挥发油。通过气相色谱-质谱联用（GC-MS）对挥发油的成分进行分离和鉴定。
结果
共鉴定出72种成分，占总峰面积的98.15%。该挥发油对K-562人肿瘤细胞系具有较强的抗肿瘤活性，IC50为1.76μg/mL。对3种细菌也表现出中等程度的抗菌活性。
结论
鹰不泊挥发油含有多种活性成分。该结果为鹰不泊的药理深入研究提供了科学参考。
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