[毛叶木姜子果实挥发油的成分及抗肿瘤活性]
[Composition and antitumor activities of essential oil from the fruits of Dasymaschalon trichophorum].
作者信息
Li Xiao-bao, Chen Guang-ying, Song Xiao-ping, Han Chang-ri, Zheng Cai-juan
出版信息
Zhong Yao Cai. 2013 Nov;36(11):1786-8.
OBJECTIVE
To study the chemical components and antitumor activities of essential oil from the fruits of Dasymaschalon trichophorum.
METHODS
The essential oil from the fruits of Dasymaschalon trichophorum was extracted by steam-stilling and analyzed by GC-MS. The inhibitory effect of extract of Dasymaschalon trichophorum on SPCA-1,BEL-7402, SGC-7901 and K-562 cell proliferation was assayed using the MTU.
RESULTS
GC-MS result showed that there were 55 peaks and 30 compounds were identified which weighed 74.98%. The major components were nerolidol (19.887%), caryophyllene (16.714%) and beta-myrcene (9.29%). The essential oil exhibited strong antitumor activity against SPCA-1 human tumor cell line with IC50 value of 6.61 microg/mL.
CONCLUSION
This experiment provides scientific foundation for further utilization of Dasymaschalon trichophorum.
目的
研究毛叶巴豆果实挥发油的化学成分及抗肿瘤活性。
方法
采用水蒸气蒸馏法提取毛叶巴豆果实挥发油，并用气相色谱-质谱联用仪（GC-MS）进行分析。采用MTT法检测毛叶巴豆提取物对SPCA-1、BEL-7402、SGC-7901和K-562细胞增殖的抑制作用。
结果
GC-MS分析结果显示，共出峰55个，鉴定出30种化合物，占挥发油总量的74.98%。主要成分有橙花叔醇（19.887%）、石竹烯（16.714%）和β-月桂烯（9.29%）。该挥发油对人肿瘤细胞株SPCA-1具有较强的抗肿瘤活性，IC50值为6.61μg/mL。
结论
本实验为毛叶巴豆的进一步开发利用提供了科学依据。
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