血小板激活因子（PAF）可诱导风团和红斑皮肤反应，而不依赖于肥大细胞脱颗粒。
Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation.
机构信息
Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.
出版信息
Allergy. 2013 Feb;68(2):256-8. doi: 10.1111/all.12083.
BACKGROUND
Platelet-activating factor (PAF) causes wheal and flare responses which are abrogated by H1-antihistamines giving rise to the hypothesis that PAF-induced wheal development is secondary to histamine release from dermal mast cells. But is this hypothesis correct?
METHODS
Wheal and flare responses were induced by intradermal injection of PAF, codeine and histamine in 14 healthy volunteers. Dermal histamine and PGD2 contractions were measured using microdialysis.
RESULTS
PAF, unlike histamine and codeine, did not cause a statistically significant rise in mean histamine levels with ten persons showing negligible histamine release. Codeine caused a significant but variable histamine release, ranging from 29 to 282 ng/ml. Codeine, but not PAF or histamine, caused a small but statistically significant release of PGD2.
CONCLUSION
Wheal and flare reactions in human skin induced by PAF are not associated with histamine release and, therefore, appear to be independent of mast cell degranulation.
背景
血小板激活因子（PAF）可引起风团和红斑反应，这些反应可被 H1 抗组胺药消除，这就产生了一个假设，即 PAF 诱导的风团发展是继发于皮肤肥大细胞释放组胺。但是这个假设正确吗？
方法
在 14 名健康志愿者中，通过皮内注射 PAF、可待因和组胺来诱导风团和红斑反应。使用微透析法测量皮肤组胺和 PGD2 收缩。
结果
PAF 与组胺和可待因不同，它不会引起平均组胺水平的显著升高，其中 10 人显示出可忽略不计的组胺释放。可待因引起了显著但可变的组胺释放，范围从 29 到 282ng/ml。可待因，但不是 PAF 或组胺，引起了小但统计学上显著的 PGD2 释放。
结论
PAF 在人类皮肤中引起的风团和红斑反应与组胺释放无关，因此似乎与肥大细胞脱颗粒无关。
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