[对可待因的荨麻疹皮肤反应，一种肥大细胞反应性的测量方法]

[Urticarial skin reaction to codeine, a measure of mast cell reactivity].

作者信息

Berther T, Conroy M C, de Weck A L

出版信息

Schweiz Med Wochenschr. 1980 May 17;110(20):758-63.

Abstract

The reactivity of skin mast cells was tested in 86 probands. Introduction of various concentrations of codeine phosphate, either by intradermal injection or by prick test, produced an immediate wheal and flare response. Since the codeine skin test depends on both release of and response to histamine, it may be more useful than the conventional skin test with histamine for assessment of skin reactivity, and also for preliminary evaluation of anti-allergic agents in man.

摘要

对86名受试者的皮肤肥大细胞反应性进行了测试。通过皮内注射或点刺试验引入不同浓度的磷酸可待因，均产生即刻风团和红晕反应。由于可待因皮肤试验依赖于组胺的释放和反应，它在评估皮肤反应性方面可能比传统的组胺皮肤试验更有用，也可用于对人体抗过敏药物的初步评估。